Tet methylcytosine dioxygenase 1
Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes that in humans is encoded by the TET1 gene.[1][2]
TET1 catalyzes the conversion of the modified DNA base 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC).[3] TET1 produces 5-hmC by oxidation of 5-mC in an iron and alpha-ketoglutarate dependent manner.[4] The conversion of 5-mC to 5-hmC has been proposed as the initial step of active DNA demethylation in mammals.[4]
TET1 appears to facilitate nuclear reprogramming of somatic cells to iPS cells.[5] [6]
References
- ↑ "Entrez Gene: Tet methylcytosine dioxygenase 1". Retrieved 2012-07-26.
- ↑ Coulter JB, O'Driscoll CM, Bressler JP (2013). "Hydroquinone Increases 5-Hydroxymethylcytosine Formation through Ten Eleven Translocation 1 (TET1) 5-Methylcytosine Dioxygenase". Journal of Biological Chemistry 288 (40): 28792–28800. doi:10.1074/jbc.M113.491365. PMC 3789975. PMID 23940045.
- ↑ Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A (2009). "Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1". Science 324 (5929): 930–935. doi:10.1126/science.1170116. PMC 2715015. PMID 19372391.
- 1 2 Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y (2011). "Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine". Science 333 (6047): 1300–1303. doi:10.1126/science.1210597. PMC 3495246. PMID 21778364.
- ↑ Pera, Martin F (25 November 2013). "Epigenetics, vitamin supplements and cellular reprogramming". Nature Genetics 45 (12): 1412–1413. doi:10.1038/ng.2834.
- ↑ Gao, S., Chen, J. (2015). "The Combination of Tet1 with Oct4 Generates High-Quality Mouse-Induced Pluripotent Stem Cells". STEM CELLS 33: 686–698. doi:10.1002/stem.1879.
Further reading
- Abdel-Wahab O, Mullally A, Hedvat C, Garcia-Manero G, Patel J, Wadleigh M, Malinge S, Yao J, Kilpivaara O, Bhat R, Huberman K, Thomas S, Dolgalev I, Heguy A, Paietta E, Le Beau MM, Beran M, Tallman MS, Ebert BL, Kantarjian HM, Stone RM, Gilliland DG, Crispino JD, Levine RL (2009). "Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies". Blood 114 (1): 144–147. doi:10.1182/blood-2009-03-210039. PMC 2710942. PMID 19420352.
- Lorsbach RB, Moore J, Mathew S, Raimondi SC, Mukatira ST, Downing JR (2003). "TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23)". Leukemia 17 (3): 637–641. doi:10.1038/sj.leu.2402834. PMID 12646957.
- Morgan AR, Hamilton G, Turic D, Jehu L, Harold D, Abraham R, Hollingworth P, Moskvina V, Brayne C, Rubinsztein DC, Lynch A, Lawlor B, Gill M, O'Donovan M, Powell J, Lovestone S, Williams J, Owen MJ (2008). "Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease". American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 147B (6): 727–731. doi:10.1002/ajmg.b.30670. PMID 18163421.
- Ono R, Taki T, Taketani T, Taniwaki M, Kobayashi H, Hayashi Y (2002). "LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)". Cancer Research 62 (14): 4075–4080. PMID 12124344.
- Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, Ito S, Yang C, Wang P, Xiao MT, Liu LX, Jiang WQ, Liu J, Zhang JY, Wang B, Frye S, Zhang Y, Xu YH, Lei QY, Guan KL, Zhao SM, Xiong Y (2011). "Oncometabolite 2-Hydroxyglutarate is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases". Cancer Cell 19 (1): 17–30. doi:10.1016/j.ccr.2010.12.014. PMC 3229304. PMID 21251613.
- Guo JU, Su Y, Zhong C, Ming GL, Song H (2011). "Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain". Cell 145 (3): 423–434. doi:10.1016/j.cell.2011.03.022. PMC 3088758. PMID 21496894.
- Frauer C, Rottach A, Meilinger D, Bultmann S, Fellinger K, Hasenöder S, Wang M, Qin W, Söding J, Spada F, Leonhardt H (2011). "Different Binding Properties and Function of CXXC Zinc Finger Domains in Dnmt1 and Tet1". PLoS ONE 6 (2): e16627. doi:10.1371/journal.pone.0016627. PMC 3032784. PMID 21311766.
- Langemeijer SM, Aslanyan MG, Jansen JH (2009). "TET proteins in malignant hematopoiesis". Cell cycle (Georgetown, Tex.) 8 (24): 4044–4048. doi:10.4161/cc.8.24.10239. PMID 19923888.
- Mohr F, Döhner K, Buske C, Rawat VP (2011). "TET genes: New players in DNA demethylation and important determinants for stemness". Experimental Hematology 39 (3): 272–81. doi:10.1016/j.exphem.2010.12.004. PMID 21168469.
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