Tet methylcytosine dioxygenase 1

Tet methylcytosine dioxygenase 1
Identifiers
Symbols TET1 ; CXXC6; LCX; MLL-TET1; TET1-MLL; bA119F7.1
External IDs OMIM: 607790 HomoloGene: 12735 GeneCards: TET1 Gene
EC number 1.14.11.n2
Orthologs
Species Human Mouse
Entrez 80312 52463
Ensembl ENSG00000138336 ENSMUSG00000047146
UniProt Q8NFU7 Q3URK3
RefSeq (mRNA) NM_030625 NM_001253857
RefSeq (protein) NP_085128 NP_001240786
Location (UCSC) Chr 10:
68.56 – 68.69 Mb
Chr 10:
62.8 – 62.9 Mb
PubMed search

Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes that in humans is encoded by the TET1 gene.[1][2]

TET1 catalyzes the conversion of the modified DNA base 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC).[3] TET1 produces 5-hmC by oxidation of 5-mC in an iron and alpha-ketoglutarate dependent manner.[4] The conversion of 5-mC to 5-hmC has been proposed as the initial step of active DNA demethylation in mammals.[4]

TET1 appears to facilitate nuclear reprogramming of somatic cells to iPS cells.[5] [6]

References

  1. "Entrez Gene: Tet methylcytosine dioxygenase 1". Retrieved 2012-07-26.
  2. Coulter JB, O'Driscoll CM, Bressler JP (2013). "Hydroquinone Increases 5-Hydroxymethylcytosine Formation through Ten Eleven Translocation 1 (TET1) 5-Methylcytosine Dioxygenase". Journal of Biological Chemistry 288 (40): 28792–28800. doi:10.1074/jbc.M113.491365. PMC 3789975. PMID 23940045.
  3. Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A (2009). "Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1". Science 324 (5929): 930–935. doi:10.1126/science.1170116. PMC 2715015. PMID 19372391.
  4. 1 2 Ito S, Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y (2011). "Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine". Science 333 (6047): 1300–1303. doi:10.1126/science.1210597. PMC 3495246. PMID 21778364.
  5. Pera, Martin F (25 November 2013). "Epigenetics, vitamin supplements and cellular reprogramming". Nature Genetics 45 (12): 1412–1413. doi:10.1038/ng.2834.
  6. Gao, S., Chen, J. (2015). "The Combination of Tet1 with Oct4 Generates High-Quality Mouse-Induced Pluripotent Stem Cells". STEM CELLS 33: 686–698. doi:10.1002/stem.1879.

Further reading

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