TERRA (biology)

TERRA in biology is an abbreviation for "TElomeric Repeat-containing RNA".[1] TERRA is RNA that is transcribed from telomeres — the repeating 6-nucleotide sequences that cap the ends of chromosomes. TERRA functions with shelterin to inhibit telomere lengthening by telomerase enzyme.[1] TERRA can also regulate telomere length by increasing euchromatin formation.[2] On the other hand, nonsense-mediated decay factor enrichment at telomeres may exist to prevent TERRA inhibition of telomerase.[1] TERRA levels vary during the cell cycle, decreasing during S phase, and increasing in the transition from G2 phase to G1 phase.[2]

References

  1. ↑ 1.0 1.1 1.2 Luke B, Lingner J (2009). "TERRA: telomeric repeat-containing RNA". The EMBO Journal 28 (17): 2503–2510. doi:10.1038/emboj.2009.166. PMC 2722245. PMID 19629047.
  2. ↑ 2.0 2.1 Wang C, Zhao L, Lu S (2015). "Role of TERRA in the regulation of telomere length". International Journal of Biological Sciences 11 (3): 316–323. doi:10.7150/ijbs.10528. PMC 4323371. PMID 25678850.


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