TCF7

Transcription factor 7 (T-cell specific, HMG-box)

PDB rendering based on 2lef.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2lef

Identifiers

Symbols

TCF7 ; TCF-1

External IDs

OMIM: 189908 MGI: 98507 HomoloGene: 135816 ChEMBL: 1075124 GeneCards: TCF7 Gene

Gene ontology
Molecular function	• core promoter binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • chromatin binding • transcription factor activity, sequence-specific DNA binding • protein binding • beta-catenin binding • sequence-specific DNA binding • transcription regulatory region DNA binding
Cellular component	• nucleus • nucleoplasm • transcription factor complex • nuclear euchromatin
Biological process	• negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • immune response • neural tube development • embryonic genitalia morphogenesis • T cell receptor V(D)J recombination • regulation of cell proliferation • canonical Wnt signaling pathway involved in negative regulation of apoptotic process • alpha-beta T cell differentiation • embryonic digestive tract morphogenesis • embryonic hindgut morphogenesis • generation of neurons • canonical Wnt signaling pathway • cellular response to interleukin-4
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
134.11 – 134.15 Mb

Chr 11:
52.25 – 52.28 Mb

PubMed search

Transcription factor 7 is a protein that in humans is encoded by the TCF7 gene.^[1]

References

↑ "Entrez Gene: TCF7 transcription factor 7 (T-cell specific, HMG-box)".

van de Wetering M, Oosterwegel M, Holstege F, et al. (1992). "The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.". J. Biol. Chem. 267 (12): 8530–6. PMID 1569101.
van de Wetering M, Oosterwegel M, Dooijes D, Clevers H (1991). "Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.". EMBO J. 10 (1): 123–32. PMC 452620. PMID 1989880.
Castrop J, van Wichen D, Koomans-Bitter M, et al. (1995). "The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes.". Blood 86 (8): 3050–9. PMID 7579399.
Mayer K, Wolff E, Clevers H, Ballhausen WG (1995). "The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA.". Biochim. Biophys. Acta 1263 (2): 169–72. doi:10.1016/0167-4781(95)00108-s. PMID 7640309.
Van de Wetering M, Castrop J, Korinek V, Clevers H (1996). "Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties.". Mol. Cell. Biol. 16 (3): 745–52. PMC 231054. PMID 8622675.
Korinek V, Barker N, Willert K, et al. (1998). "Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse.". Mol. Cell. Biol. 18 (3): 1248–56. PMC 108837. PMID 9488439.
Roose J, Molenaar M, Peterson J, et al. (1998). "The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors.". Nature 395 (6702): 608–12. doi:10.1038/26989. PMID 9783587.
Roose J, Huls G, van Beest M, et al. (1999). "Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1.". Science 285 (5435): 1923–6. doi:10.1126/science.285.5435.1923. PMID 10489374.
Brantjes H, Roose J, van De Wetering M, Clevers H (2001). "All Tcf HMG box transcription factors interact with Groucho-related co-repressors.". Nucleic Acids Res. 29 (7): 1410–9. doi:10.1093/nar/29.7.1410. PMC 31284. PMID 11266540.
Batlle E, Henderson JT, Beghtel H, et al. (2002). "Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.". Cell 111 (2): 251–63. doi:10.1016/S0092-8674(02)01015-2. PMID 12408869.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Noble JA, White AM, Lazzeroni LC, et al. (2003). "A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes.". Diabetes 52 (6): 1579–82. doi:10.2337/diabetes.52.6.1579. PMID 12765974.
Ioannidis V, Kunz B, Tanamachi DM, et al. (2003). "Initiation and limitation of Ly-49A NK cell receptor acquisition by T cell factor-1.". J. Immunol. 171 (2): 769–75. doi:10.4049/jimmunol.171.2.769. PMID 12847244.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Smit L, Baas A, Kuipers J, et al. (2004). "Wnt activates the Tak1/Nemo-like kinase pathway.". J. Biol. Chem. 279 (17): 17232–40. doi:10.1074/jbc.M307801200. PMID 14960582.
Smith SS, Patterson T, Pauza ME (2005). "Transgenic Ly-49A inhibits antigen-driven T cell activation and delays diabetes.". J. Immunol. 174 (7): 3897–905. doi:10.4049/jimmunol.174.7.3897. PMID 15778344.
Willinger T, Freeman T, Herbert M, et al. (2006). "Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo.". J. Immunol. 176 (3): 1439–46. doi:10.4049/jimmunol.176.3.1439. PMID 16424171.

PDB gallery

2lef: LEF1 HMG DOMAIN (FROM MOUSE), COMPLEXED WITH DNA (15BP), NMR, 12 STRUCTURES

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TCF7

References

Further reading