Supercentenarian

A supercentenarian (sometimes hyphenated as super-centenarian) is someone who has lived to or passed their 110th birthday. This age is achieved by about one in 1,000 centenarians.[1] Anderson et al. concluded that supercentenarians live a life typically free of major age-related diseases until shortly before maximum human lifespan is reached between 110 and 115 years.[2]

Incidence

There are estimated to be 300–450 living supercentenarians[3] in the world, though only 54 verified cases are known.[4] A study conducted in 2010 showed that the countries with the most known supercentenarians (living and dead, in order of total) were the United States,[5] Japan, the United Kingdom, France, and Italy.[6]

The first verified supercentenarians in human history died in the late nineteenth century. Until the 1980s, the oldest age attained by supercentenarians was 115, but this has now been surpassed.

Etymology

The term "supercentenarian" has been in existence since at least the nineteenth century.[7][8] The term "ultracentenarian" was also used to describe someone well over 100[9] (Norris McWhirter, editor of Guinness World Records, used the word in correspondence with age claims researcher A. Ross Eckler, Jr. in 1976), and was further popularised in 1991 by William Strauss and Neil Howe in their book entitled Generations. Early references tend to mean simply "someone well over 100", but the 110-and-over cutoff is the accepted criterion of demographers.

History

While claims of extreme age have persisted from the earliest times in history, the earliest supercentenarian accepted by Guinness World Records is Dutchman Thomas Peters (reportedly 1745–1857). Scholars such as French demographer Jean-Marie Robine, however, consider Geert Adriaans Boomgaard, also of the Netherlands, who turned 110 in 1898, to be the first verifiable case, as the alleged evidence for Peters has apparently been lost. The evidence for the 112 years of Englishman William Hiseland (reportedly 1620–1733) does not meet the standards required by Guinness World Records. Norwegian Church records, the accuracy of which is subject to dispute, also show what appear to be several supercentenarians who lived in the south-central part of present-day Norway during the 16th and 17th centuries, including Johannes Torpe (1549–1664), and Knud Erlandson Etun (1659–1770), both residents of Valdres, Oppland, Norway.

In 1902, Margaret Ann Neve, born in 1792, became the first verified female supercentenarian.

Jeanne Calment of France, who died in 1997 aged 122 years, 164 days, had the longest human lifespan documented. The oldest verified man ever recorded is Jiroemon Kimura of Japan, who died in 2013 aged 116 years and 54 days.

Over 1,500 supercentenarians have been documented in history.[10] It is likely that more have lived, but the majority of claims to have lived to this age do not have sufficient documentary support to be validated. This is slowly changing as those born after birth registration was standardized in more countries and parts of countries attain supercentenarian age.

Morbidity

Research on the morbidity of supercentenarians has found that they remain free of major age-related diseases (e.g., stroke, cardiovascular disease, dementia, cancer, Parkinson's disease, and diabetes) until the very end of life when they die of exhaustion of organ reserve, which is the ability to return organ function to homeostasis.[2] About 10% of supercentenarians survive until the last 3 months of life without major age-related diseases as compared to only 4% of semisupercentenarians (age range 105–109 years) and 3% of centenarians.[2]

By measuring the biological age of various tissues from supercentenarians, researchers may be able to identify tissues that are protected from aging effects. According to a study of 30 different body parts from a 112-year-old female supercentenarian and younger controls, the cerebellum is protected from aging according to an epigenetic biomarker of tissue age known as epigenetic clock: it is about 15 years younger than expected in a centenarian.[11] These findings could explain why the cerebellum exhibits fewer neuropathological hallmarks of age related dementias compared to other brain regions.

See also

References

  1. ↑ Maier, H., Gampe, J., Jeune, B., Robine, J.-M., Vaupel, J. W. (Eds.) (2010). Supercentenarians. Germany: Max Planck Institute for Demographic Research. p. 325. ISBN 978-3-642-11519-6.
  2. 1 2 3 Anderson, Stacy L.; Sebastiani, Paola; Dworkis, Daniel A.; Feldman, Lori; Perls, Thomas T. (2012). "Health Span Approximates Life Span Among Many Supercentenarians: Compression of Morbidity at the Approximate Limit of Life Span". The Journals of Gerontology: Series A 67A: 395–405. doi:10.1093/gerona/glr223. Retrieved 28 February 2014.
  3. ↑ Validated living supercentenarians
  4. ↑ http://supercentenarian-research-foundation.org/TableE.aspx
  5. ↑ Rosenwaike, Ira; Stone, Leslie F. (2003). "Verification of the Ages of Supercentenarians in the United States: Results of a Matching Study". Demography 40 (4): 727–739. doi:10.1353/dem.2003.0038. JSTOR 1515205.
  6. ↑ The 2010 study of countries with most supercentenarians
  7. ↑ "Death of a Super-centenarian". The Tralee Chronicle and Killarney Echo. 15 November 1870. Retrieved 5 February 2015.
  8. ↑ "The Doctors and the Microbes". The Inter Ocean. 10 October 1897. Retrieved 5 February 2015.
  9. ↑ Gibb, G. (1876). "Ultra-Centenarian Longevity". The Journal of the Anthropological Institute of Great Britain and Ireland (Royal Anthropological Institute of Great Britain and Ireland) 5: 82–101. doi:10.2307/2841365. Retrieved 6 February 2015.
  10. ↑ Gerontology Research Group: Verified Supercentenarians (Ranked By Age) as of January 1, 2014
  11. ↑ Horvath S, Mah V, Lu AT, Woo JS, Choi OW, Jasinska AJ, Riancho JA, Tung S, Coles NS, Braun J, Vinters HV, Coles LS (2015). "The cerebellum ages slowly according to the epigenetic clock." (PDF). Age (Albany US) 7 (5): 96. doi:10.1186/s13059-015-0649-6. PMID 25968125.

External links

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