Sulfur dioxygenase

Sulfur dioxygenase
Identifiers
EC number 1.13.11.18
CAS number 37256-58-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Sulfur dioxygenase (EC 1.13.11.18, sulfur oxygenase, sulfur:oxygen oxidoreductase) is an enzyme with system name S-sulfanylglutathione:oxygen oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

sulfur + O2 + H2O \rightleftharpoons sulfite + 2 H+ (overall reaction)
(1a) glutathione + sulfur \rightleftharpoons S-sulfanylglutathione (spontaneous reaction)
(1b) S-sulfanylglutathione + O2 + H2O \rightleftharpoons glutathione + sulfite + 2 H+

This enzyme contains iron.

In humans, sulfur dioxygenase is needed to detoxify sulfide.[3]

References

  1. ↑ Suzuki, I. and Silver, M. (1966). "The initial product and properties of the sulfur-oxidizing enzyme of thiobacilli". Biochim. Biophys. Acta 122: 22–33. doi:10.1016/0926-6593(66)90088-9. PMID 5968172.
  2. ↑ Rohwerder, T. and Sand, W. (2003). "The sulfane sulfur of persulfides is the actual substrate of the sulfur-oxidizing enzymes from Acidithiobacillus and Acidiphilium spp". Microbiology 149: 1699–1710. doi:10.1099/mic.0.26212-0. PMID 12855721.
  3. ↑ Viscomi, C.; Burlina, A.B.; Dweikat, I.; Savoiardo, M.; Lamperti, C.; Hildebrandt, T.; Tiranti, V.; Zeviani, M. (2010). "Combined treatment with oral metronidazole and N-acetylcysteine is effective in ethylmalonic encephalopathy". Nat Med 16: 869–71. doi:10.1038/nm.2188. PMID 20657580.

External links

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