Stigmastanol
 | |
| Names | |
|---|---|
| IUPAC name
(3S,5S,8R,9S,10S,13R,14S,17R)-17-((2R,5R)-5-ethyl-6-methylheptan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-ol | |
| Other names
(3β)-Stigmastan-3-ol; (3β,5α)-Stigmastan-3-ol; β-Sitostanol; Dihydrositosterin; Dihydrositosterol; Dihydro-β-sitosterol; Fucostanol; Spinastanol; 24α-Ethylcholestanol | |
| Identifiers | |
83-45-4  | |
| ChEBI | CHEBI:89400 |
| ChEMBL | ChEMBL252364 |
| ChemSpider | 13078158 |
| Jmol interactive 3D | Image |
| PubChem | 15559396 |
| UNII | C2NJ9WO6O7 |
| |
| Properties | |
| C29H52O | |
| Molar mass | 416.73 g·mol−1 |
| Boiling point | 139.4 to 139.8 °C (282.9 to 283.6 °F; 412.5 to 412.9 K)[1] |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Stigmastanol (sitostanol) is a phytosterol found in a variety of plant sources. Similar to sterol esters and stanol esters, stigmastanol inhibits the absorption of cholesterol from the diet.[2][3][4] Animal studies suggest that it also inhibits biosynthesis of cholesterol in the liver.[2]
Stigmastanol is the product of the reduction of β-sitosterol[5] and the hydrogenation of stigmasterol.[6]
See also
- Stigmasterol, a closely related sterol
References
- ↑ Sandqvist, Hakan; Bengtsson, Edvard (1931). "The empirical formula of sitosterol". Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen 64B: 2167–2171.
- 1 2 Batta, Ashok K.; Xu, Guorong; Honda, Akira; Miyazaki, Teruo; Salen, Gerald (2006). "Stigmasterol reduces plasma cholesterol levels and inhibits hepatic synthesis and intestinal absorption in the rat". Metabolism, Clinical and Experimental 55 (3): 292–299. doi:10.1016/j.metabol.2005.08.024.
- ↑ Heinemann T; Pietruck B; Kullak-Ublick G; von Bergmann K (1988). "Comparison of sitosterol and sitostanol on inhibition of intestinal cholesterol absorption". Agents and actions. Supplements 26: 117–122. PMID 3265272.
- ↑ Heinemann T; Kullak-Ublick G A; Pietruck B; von Bergmann K (1991). "Mechanisms of action of plant sterols on inhibition of cholesterol absorption. Comparison of sitosterol and sitostanol". European journal of clinical pharmacology 40 (Suppl 1): S59–63. doi:10.1007/BF01409411. PMID 2044646.
- ↑ Thomasson Crompton, David William; Nickol, Brent B. (1985). Biology of the Acanthocephala. Cambridge University Press. p. 185. ISBN 9780521246743.
- ↑ Paxena, P. B. (2007). Chemistry of Alkaloids. Discovery Publishing Hous. p. 231. ISBN 9788183563161.
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