Statine

This article is about the amino acid. For the group of cholesterol lowering drugs, see Statin.

Statine
Names

IUPAC name (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid
Identifiers
CAS Number	49642-07-1
Abbreviations	AHMHA, Sta
ChEBI	CHEBI:45769
ChemSpider	110446
Jmol interactive 3D	Image
PubChem	123915
InChI InChI=1S/C8H17NO3/c1-5(2)3-6(9)7(10)4-8(11)12/h5-7,10H,3-4,9H2,1-2H3,(H,11,12)/t6-,7-/m0/s1 Key: DFVFTMTWCUHJBL-BQBZGAKWSA-N
SMILES N[C@@H](CC(C)C)[C@@H](O)CC(O)=O
Properties
Chemical formula	C₈H₁₇NO₃
Molar mass	175.23 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Statine is a gamma amino acid that occurs twice in the sequence of pepstatin, a protease inhibitor that is active against pepsin and other acid proteases.^[1] It is thought to be responsible for the inhibitory activity of pepstatin because it mimics the tetrahedral transition state of peptide catalysis.^[2]

References

↑ Umezawa, H.; Aoyagi, T.; Morishima, H.; Matsuzaki, M.; Hamada, M.; Takeuchi, T. (1970). "Pepstatin, a new pepsin inhibitor produced by Actinomycetes". The Journal of antibiotics 23 (5): 259–262. doi:10.7164/antibiotics.23.259. PMID 4912600.
↑ Marciniszyn Jr, J.; Hartsuck, J. A.; Tang, J. (1976). "Mode of inhibition of acid proteases by pepstatin". The Journal of Biological Chemistry 251 (22): 7088–7094. PMID 993206.

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