SRA1

Steroid receptor RNA activator 1

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2MGX, 4NBO

Identifiers

Symbols

SRA1 ; SRA; SRAP; STRAA1; pp7684

External IDs

OMIM: 603819 MGI: 1344414 HomoloGene: 11906 GeneCards: SRA1 Gene

Gene ontology
Molecular function	• transcription coactivator activity • protein binding • ligand-dependent nuclear receptor binding • ligand-dependent nuclear receptor transcription coactivator activity
Cellular component	• nucleus • nucleoplasm • cytoplasm • plasma membrane • microtubule cytoskeleton • ribonucleoprotein complex • intercellular bridge
Biological process	• transcription, DNA-templated • regulation of transcription, DNA-templated • apoptotic process • cell proliferation • cell differentiation • regulation of apoptotic process • positive regulation of receptor activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
140.54 – 140.56 Mb

Chr 18:
36.67 – 36.68 Mb

PubMed search

Steroid receptor RNA activator 1 also known as steroid receptor RNA activator protein (SRAP) is a protein that in humans is encoded by the SRA1 gene.^[1]^[2] The mRNA transcribed from the SRA1 gene is a component of the ribonucleoprotein complex containing NCOA1. This functional RNA also encodes a protein.^[3]

Function

This gene is involved in transcriptional coactivation by steroid receptor. There is currently data suggesting this gene encodes both a non-coding RNA that functions as part of a ribonucleoprotein complex and a protein coding mRNA. Increased expression of both the transcript and the protein is associated with cancer.^[2]

Interactions

SRA1 has been shown to interact with:

The SRAP has been shown to interact with its SRA RNA counterpart via its RRM-like domain interacting with the functional sub-structure STR7 of SRA RNA.^[6]

References

↑ Lanz RB, McKenna NJ, Onate SA, Albrecht U, Wong J, Tsai SY, Tsai MJ, O'Malley BW (Apr 1999). "A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex". Cell 97 (1): 17–27. doi:10.1016/S0092-8674(00)80711-4. PMID 10199399.
1 2 "Entrez Gene: SRA1 steroid receptor RNA activator 1".
↑ Chooniedass-Kothari S, Emberley E, Hamedani MK, Troup S, Wang X, Czosnek A, Hube F, Mutawe M, Watson PH, Leygue E (May 2004). "The steroid receptor RNA activator is the first functional RNA encoding a protein". FEBS Lett. 566 (1–3): 43–7. doi:10.1016/j.febslet.2004.03.104. PMID 15147866.
1 2 3 Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (March 2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". EMBO J. 20 (6): 1341–52. doi:10.1093/emboj/20.6.1341. PMC 145523. PMID 11250900.
↑ Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM (May 2001). "Sharp, an inducible cofactor that integrates nuclear receptor repression and activation". Genes Dev. 15 (9): 1140–51. doi:10.1101/gad.871201. PMC 312688. PMID 11331609.
↑ Hubé F, Velasco G, Rollin J, Furling D, Francastel C (Sep 2010). "Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation". Nucleic Acids Res. 39 (2): 513–25. doi:10.1093/nar/gkq833. PMC 3025577. PMID 20855289.

Ulveling D, Francastel C, Hubé F. (2010). "When one is better than two: RNA with dual functions". Biochimie 93 (4): 633–644. doi:10.1016/j.biochi.2010.11.004. PMID 21111023.
Hubé F, Velasco G, Rollin J, Furling D, Francastel C (2010). "Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation". Nucleic Acids Res. 39 (2): 513–25. doi:10.1093/nar/gkq833. PMC 3025577. PMID 20855289.
Cooper C, Guo J, Yan Y, Chooniedass-Kothari S, Hube F, Hamedani MK, Murphy LC, Myal Y, Leygue E (2009). "Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides". Nucleic Acids Res. 37 (13): 4518–31. doi:10.1093/nar/gkp441. PMC 2715257. PMID 19483093.
Hube F, Guo J, Chooniedass-Kothari S, Cooper C, Hamedani MK, Dibrov AA, Blanchard AA, Wang X, Deng G, Myal Y, Leygue E. (2006). "Alternative splicing of the first intron of the steroid receptor RNA activator (SRA) participates in the generation of coding and noncoding RNA isoforms in breast cancer cell lines". DNA Cell Biol. 25 (7): 418–28. doi:10.1089/dna.2006.25.418. PMID 16848684.
Leygue E, Dotzlaw H, Watson PH, Murphy LC (1999). "Expression of the steroid receptor RNA activator in human breast tumors". Cancer Res. 59 (17): 4190–3. PMID 10485452.
Murphy LC, Simon SL, Parkes A, et al. (2000). "Altered expression of estrogen receptor coregulators during human breast tumorigenesis". Cancer Res. 60 (22): 6266–71. PMID 11103781.
Cavarretta IT, Mukopadhyay R, Lonard DM, et al. (2002). "Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation". Mol. Endocrinol. 16 (2): 253–70. doi:10.1210/me.16.2.253. PMID 11818499.
Kucera T, Waltner-Law M, Scott DK, et al. (2002). "A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1". J. Biol. Chem. 277 (29): 26098–102. doi:10.1074/jbc.M204013200. PMID 12118039.
Ueda T, Mawji NR, Bruchovsky N, Sadar MD (2002). "Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells". J. Biol. Chem. 277 (41): 38087–94. doi:10.1074/jbc.M203313200. PMID 12163482.
Lanz RB, Razani B, Goldberg AD, O'Malley BW (2003). "Distinct RNA motifs are important for coactivation of steroid hormone receptors by steroid receptor RNA activator (SRA)". Proc. Natl. Acad. Sci. U.S.A. 99 (25): 16081–6. doi:10.1073/pnas.192571399. PMC 138568. PMID 12444263.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Emberley E, Huang GJ, Hamedani MK, et al. (2003). "Identification of new human coding steroid receptor RNA activator isoforms". Biochem. Biophys. Res. Commun. 301 (2): 509–15. doi:10.1016/S0006-291X(02)03070-X. PMID 12565891.
Watkins RE, Davis-Searles PR, Lambert MH, Redinbo MR (2003). "Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor". J. Mol. Biol. 331 (4): 815–28. doi:10.1016/S0022-2836(03)00795-2. PMID 12909012.
Deblois G, Giguère V (2003). "Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation". J. Steroid Biochem. Mol. Biol. 85 (2–5): 123–31. doi:10.1016/S0960-0760(03)00225-5. PMID 12943696.
Lanz RB, Chua SS, Barron N, et al. (2003). "Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo". Mol. Cell. Biol. 23 (20): 7163–76. doi:10.1128/MCB.23.20.7163-7176.2003. PMC 230309. PMID 14517287.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Fleming FJ, Hill AD, McDermott EW, et al. (2004). "Differential recruitment of coregulator proteins steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid receptors to the estrogen receptor-estrogen response element by beta-estradiol and 4-hydroxytamoxifen in human breast cancer". J. Clin. Endocrinol. Metab. 89 (1): 375–83. doi:10.1210/jc.2003-031048. PMID 14715875.
Xu B, Koenig RJ (2004). "An RNA-binding domain in the thyroid hormone receptor enhances transcriptional activation". J. Biol. Chem. 279 (32): 33051–6. doi:10.1074/jbc.M404930200. PMID 15180993.
Zhao X, Patton JR, Davis SL, et al. (2004). "Regulation of nuclear receptor activity by a pseudouridine synthase through posttranscriptional modification of steroid receptor RNA activator". Mol. Cell 15 (4): 549–58. doi:10.1016/j.molcel.2004.06.044. PMID 15327771.
Coleman KM, Lam V, Jaber BM, et al. (2004). "SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity". Biochem. Biophys. Res. Commun. 323 (1): 332–8. doi:10.1016/j.bbrc.2004.08.090. PMID 15351741.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

SRA1 human gene location in the UCSC Genome Browser.
SRA1 human gene details in the UCSC Genome Browser.

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SRA1

Function

Interactions

References

Further reading

External links