Somatostatin receptor 4
Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene.[1][2]
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.[2]
See also
References
- β Rohrer L, Raulf F, Bruns C, Buettner R, Hofstaedter F, Schule R (Jun 1993). "Cloning and characterization of a fourth human somatostatin receptor". Proc Natl Acad Sci U S A 90 (9): 4196β200. doi:10.1073/pnas.90.9.4196. PMC 46473. PMID 8483934.
- 1 2 "Entrez Gene: SSTR4 somatostatin receptor 4".
Further reading
- Patel YC (1999). "Somatostatin and its receptor family". Frontiers in neuroendocrinology 20 (3): 157β98. doi:10.1006/frne.1999.0183. PMID 10433861.
- Yamada Y, Post SR, Wang K, et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251β5. doi:10.1073/pnas.89.1.251. PMC 48214. PMID 1346068.
- Demchyshyn LL, Srikant CB, Sunahara RK, et al. (1993). "Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20". Mol. Pharmacol. 43 (6): 894β901. PMID 8100352.
- Yasuda K, Espinosa R, Davis EM, et al. (1993). "Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2". Genomics 17 (3): 785β6. doi:10.1006/geno.1993.1410. PMID 8244401.
- Yamada Y, Kagimoto S, Kubota A, et al. (1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype". Biochem. Biophys. Res. Commun. 195 (2): 844β52. doi:10.1006/bbrc.1993.2122. PMID 8373420.
- Kaupmann K, Bruns C, Hoyer D, et al. (1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Lett. 331 (1β2): 53β9. doi:10.1016/0014-5793(93)80296-7. PMID 8405411.
- Yamada Y, Stoffel M, Espinosa R, et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics 15 (2): 449β52. doi:10.1006/geno.1993.1088. PMID 8449518.
- Xu Y, Song J, Bruno JF, Berelowitz M (1993). "Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4". Biochem. Biophys. Res. Commun. 193 (2): 648β52. doi:10.1006/bbrc.1993.1673. PMID 8512564.
- Fukusumi S, Kitada C, Takekawa S, et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157β63. doi:10.1006/bbrc.1997.6252. PMID 9125122.
- de Lecea L, Ruiz-Lozano P, Danielson PE, et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics 42 (3): 499β506. doi:10.1006/geno.1997.4763. PMID 9205124.
- JaΓ―s P, Terris B, Ruszniewski P, et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". Eur. J. Clin. Invest. 27 (8): 639β44. doi:10.1046/j.1365-2362.1997.1740719.x. PMID 9279525.
- Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest". Mol. Endocrinol. 13 (1): 82β90. doi:10.1210/me.13.1.82. PMID 9892014.
- Forssell-Aronsson EB, Nilsson O, BejegΓ₯rd SA, et al. (2000). "111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors". J. Nucl. Med. 41 (4): 636β42. PMID 10768564.
- Zatelli MC, Tagliati F, Taylor JE, et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". J. Clin. Endocrinol. Metab. 86 (5): 2161β9. doi:10.1210/jc.86.5.2161. PMID 11344221.
- Talme T, Ivanoff J, HΓ€gglund M, et al. (2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3". Clin. Exp. Immunol. 125 (1): 71β9. doi:10.1046/j.1365-2249.2001.01577.x. PMC 1906108. PMID 11472428.
- Pasquali D, Notaro A, Esposito D, et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175β9. PMID 11753241.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865β71. doi:10.1038/414865a. PMID 11780052.
- Papotti M, Bongiovanni M, Volante M, et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Arch. 440 (5): 461β75. doi:10.1007/s00428-002-0609-x. PMID 12021920.
External links
- "Somatostatin Receptors: sst4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- somatostatin receptor subtype-4 at the US National Library of Medicine Medical Subject Headings (MeSH)
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