Small nuclear ribonucleoprotein polypeptide F

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3CW1, 3PGW, 3S6N, 4F7U, 4PJO, 4V98, 4WZJ

Identifiers

Symbols

SNRPF ; SMF; Sm-F; snRNP-F

External IDs

OMIM: 603541 MGI: 1917128 HomoloGene: 130366 GeneCards: SNRPF Gene

Gene ontology
Molecular function	• RNA binding • protein binding
Cellular component	• nucleoplasm • spliceosomal complex • U7 snRNP • U1 snRNP • U4 snRNP • U12-type spliceosomal complex • small nucleolar ribonucleoprotein complex • cytosol • small nuclear ribonucleoprotein complex • methylosome • pICln-Sm protein complex • SMN-Sm protein complex • catalytic step 2 spliceosome
Biological process	• spliceosomal snRNP assembly • mRNA splicing, via spliceosome • transcription from RNA polymerase II promoter • termination of RNA polymerase II transcription • histone mRNA metabolic process • RNA splicing • gene expression • mRNA 3'-end processing • ncRNA metabolic process • activation of mitophagy in response to mitochondrial depolarization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
95.86 – 95.9 Mb

Chr 10:
93.58 – 93.59 Mb

PubMed search

Small nuclear ribonucleoprotein F is a protein that in humans is encoded by the SNRPF gene.^[1]^[2]

Interactions

Small nuclear ribonucleoprotein polypeptide F has been shown to interact with DDX20,^[3] Small nuclear ribonucleoprotein D2^[4] and Small nuclear ribonucleoprotein polypeptide E.^[4]

References

↑ Hermann H, Fabrizio P, Raker VA, Foulaki K, Hornig H, Brahms H, Luhrmann R (June 1995). "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions". EMBO J 14 (9): 2076–88. PMC 398308. PMID 7744013.
↑ "Entrez Gene: SNRPF small nuclear ribonucleoprotein polypeptide F".
↑ Charroux, B; Pellizzoni L; Perkinson R A; Shevchenko A; Mann M; Dreyfuss G (December 1999). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems". J. Cell Biol. (UNITED STATES) 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. ISSN 0021-9525. PMC 2168095. PMID 10601333.
1 2 Fury, M G; Zhang W; Christodoulopoulos I; Zieve G W (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. (UNITED STATES) 237 (1): 63–9. doi:10.1006/excr.1997.3750. ISSN 0014-4827. PMID 9417867.

Sauterer RA, Goyal A, Zieve GW (1990). "Cytoplasmic assembly of small nuclear ribonucleoprotein particles from 6 S and 20 S RNA-free intermediates in L929 mouse fibroblasts". J. Biol. Chem. 265 (2): 1048–58. PMID 1688550.
Feeney RJ, Sauterer RA, Feeney JL, Zieve GW (1989). "Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles". J. Biol. Chem. 264 (10): 5776–83. PMID 2522439.
Woppmann A, Rinke J, Lührmann R (1989). "Direct cross-linking of snRNP proteins F and 70K to snRNAs by ultra-violet radiation in situ". Nucleic Acids Res. 16 (23): 10985–1004. doi:10.1093/nar/16.23.10985. PMC 338992. PMID 2974540.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Plessel G, Lührmann R, Kastner B (1997). "Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core". J. Mol. Biol. 265 (2): 87–94. doi:10.1006/jmbi.1996.0713. PMID 9020971.
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
Kambach C, Walke S, Young R, et al. (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. PMID 10025403.
Bühler D, Raker V, Lührmann R, Fischer U (2000). "Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy". Hum. Mol. Genet. 8 (13): 2351–7. doi:10.1093/hmg/8.13.2351. PMID 10556282.
Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin4: A Novel Component of the Smn Complex That Is Found in Both Gems and Nucleoli". J. Cell Biol. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein–Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMC 140196. PMID 11226169.
Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
Friesen WJ, Wyce A, Paushkin S, et al. (2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ma Y, Dostie J, Dreyfuss G, Van Duyne GD (2005). "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure". Structure 13 (6): 883–92. doi:10.1016/j.str.2005.03.014. PMID 15939020.

RNA-binding protein: Ribonucleoproteins

snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 spliceosomal RNA SNRNP200

hnRNP	A0 C L R

Other transcription	Telomerase

Translation	Ribosome

Vault ribonucleoprotein particles	Major vault protein

Other	Signal recognition particle

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Small nuclear ribonucleoprotein polypeptide F

Interactions

References

Further reading