Slow-reacting substance of anaphylaxis
The Slow-reacting substance of anaphylaxis or SRS-A is a mixture of the leukotrienes LTC4, LTD4 and LTE4. Mast cells secrete it during the anaphylactic reaction, inducing inflammation.[1] It can be found in basophils.
It induces prolonged, slow contraction of smooth muscle and has a major bronchoconstrictor role in asthma.[2] Compared to histamine, it is approximately 5000 times more potent and has a slower onset but longer duration of action.
References
- ↑ "Dorland's Medical Dictionary". Retrieved December 15, 2006.
- ↑ Howard R. Morris, Graham W. Taylor, Priscilla J. Piper, John R. Tippins. "Structure of slow-reacting substance of anaphylaxis from guinea-pig lung". Retrieved December 15, 2006.
External links
- Slow Reacting Substance of Anaphylaxis at the US National Library of Medicine Medical Subject Headings (MeSH)
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