List of animals that have been cloned

This is a list of animals that have been cloned in alphabetical order. One significant aspect of this list is documenting the transition from early concerns that animal cloning procedures might be limited to a few species, that cloned animals might be physiologically abnormal, or cloning might lack utility for society.

Carp

Embryologist Tong Dizhou unsuccessfully inserted the DNA from a male Asian carp into the egg of a female Asian carp to create the first fish clone in 1963. In 1973 Dizhou inserted Asian carp DNA into a European crucian carp to create the first interspecies clone.^[1]

Cat

• In December 2001, scientists at Texas A&M University created the first cloned cat, CC (CopyCat).^[2] Even though CC is an exact copy of her host, they have different personalities; i.e. CC is shy and timid, her host on the other hand is playful and curious.^[3]
• In 2004, the first commercially cloned cat, Little Nicky, was created by Genetic Savings & Clone.^[4]

Cattle

• Gene, the first cloned calf in the world was born on February 7, 1997 at the American Breeders Service facilities in Deforest, Wisconsin, United States. Later it was transferred and kept at the Minnesota Zoo Education Center.^[5] Three more cloned calves were born in 1998.^[6]
• A Holstein heifer named "Daisy" was cloned by Dr. Xiangzhong (Jerry) Yang using ear skin cells from a high-merit cow named Aspen at the University of Connecticut in June, 1999, followed by three additional clones, Amy, Betty, and Cathy in July, 1999.^[7]
• Second Chance, a Brahman bull was cloned from Chance, a beloved celebrity bull. Second Chance was born in August, 1999 at Texas A&M University.^[8]
• Texas A&M University cloned a Black Angus bull named 86 Squared in November 2000, after cells from his donor, Bull 86, had been frozen for 15 years. Both bulls exhibit a natural resistance to brucellosis, tuberculosis and other diseases which can be transferred in meat.^[9][10]
• In 2001 researchers at Advanced Cell Technology in Worcester, Massachusetts, United States, reported that 24 successfully cloned Holsteins had been monitored from birth to the age of four. All maintained healthy stats comparable to control cattle, and reached reproductive maturity at the proper stage.^[11][12] Two of these cloned cattle successfully mated, each producing a healthy calf.^[12]
• A purebred Hereford calf clone named Chloe was born in March, 2001 at Kansas State University's purebred research unit. This was Kansas State's first cloned calf.^[13]
• Millie and Emma were two female Jersey cows cloned at the University of Tennessee in 2001. They were the first calves to be produced using standard cell-culturing techniques.
• Pampa, a Jersey calf, was the first animal cloned in Argentina (by the company Bio Sidus) in August 2002.^[14]
• A Banteng calf was successfully cloned from frozen cells using a cow as a surrogate mother in April 2003.^[15] It died when it was less than seven years old, about half the normal life of a Banteng which is an endangered species.^[16]
• An Anatolian Grey bull (Efe) was cloned in Turkey in 2009 and four female calves from the same breed (Ece, Ecem, Nilufer, Kiraz) in 2010 by the Scientific and Technological Research Council of Turkey (TÜBİTAK)^[17]
• Samrupa, the world's first Murrah buffalo calf cloned using a simple "Hand guided cloning technique" was born in February, 2009 at National Dairy Research Institute (NDRI), Karnal, India, but died due to a lung infection five days after she was born.^[18] Garima-I, a buffalo calf cloned using an "Advanced Hand guided Cloning Technique" was born in June, 2009 at the NDRI. Two years later in 2011, she died of a heart failure.^[19][20] Garima-II, another cloned calf was born in August, 2010. This buffalo was inseminated with frozen-thawed semen of a progeny tested bull and gave birth to a female calf, Mahima in January, 2013.^[21] A cloned male buffalo calf Shresth was born in August, 2010 at the NDRI^[22]
• In May 2010, Got, the first Spanish Fighting Bull was cloned by Spanish scientists.^[23]
• In 2015 the Chinese company BoyaLife announced that in partnership with the Korean company Sooam Biotech, they were planning to build a factory in Tianjin, China to produce 100,000 cloned cattle per year, starting in 2016 to supply China's growing market for quality beef.^[24]

Coyotes

Soam Biotech, Korea cloned eight coyotes in March 2011 using domestic dogs as surrogate mothers.^[25]

Deer

• Dewey was born on May 23, 2003 at Texas A&M University.^[26]

Dog

• Snuppy an Afghan hound puppy was the first dog to be cloned in April 2005 in South Korea.^[27]
• Sooam Biotech, South Korea, was reported in December 2015 to have cloned 700 dogs to date for their owners. They were also reported to charge $100,000 for each cloned puppy.^[28] One puppy was cloned from the cells of a dog that had died 12 days before.

Frog (tadpole)

In 1958, John Gurdon, then at Oxford University, explained that he had successfully cloned a frog. He did this by using intact nuclei from somatic cells from a Xenopus tadpole.^[29] This was an important extension of work of Briggs and King in 1952 on transplanting nuclei from embryonic blastula cells^[30]

Fruit flies

^[31] Five genetically identical fruit flies were produced at the lab of Dr. Vett Lloyd at Dalhousie University in Halifax, Nova Scotia, Canada in 2005.

Gaur

A species of wild cattle, the first endangered species to be cloned. In 2001 at the Trans Ova Genetics in Sioux Center, Iowa, United States, a cloned gaur was born from a surrogate domestic cow mother. However, the calf died within 48 hours.^[32]

Goat

• Downen TX 63 684 (nicknamed Megan) was cloned from a top producing Boer goat born on March 29, 2001 at Plainwell, MI.^[33]
• The Middle East's first and the world's fifth cloned goat, 'Hanna', was born at the Royan Institute in Isfahan, Iran in 2009. The cloned goat was developed in the surrogate uterus of a Bakhtiari goat. Iranian researchers were reported in 2009 to be planning to use cloned goats to eventually manufacture new medications such as antibodies and medicines for stroke victims.^[34]
• The world's first pashmina goat clone was produced at Centre of Animal Biotechnology at Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir (SKUAST), India. It was named Noori, an Arabic word referring to light. Funded by World Bank, this clone was a joint project of SKUAST and the Karnal-based National Dairy Research Institute. Pashmina goats live in Ladakh, the coldest region of Kashmir where the goat survives down to -40 °C temperatures at an altitude of 14,000 feet. Their ultra-fine cashmere wool (known as pashmina) is gathered from mountains of Ladakh after the goat sheds its wool in Spring as a natural process. Kashmir pashmina wool is the finest type of cashmere wool and is used to make kashmiri shawls, scarves, and stoles.^[35]

Horse

• In 2003, the world's first cloned horse, Prometea, was born.^[36]
• In 2006, Scamper, an extremely successful barrel racing horse, a gelding, was cloned. The resulting stallion, Clayton, became the first cloned horse to stand at stud in the US.^[37]
• In 2010, the first lived equine cloned of a Criollo horse was born in Argentina, and was the first horse clone produced in Latin-America.^[38] In the same year a cloned polo horse was sold for $800,000 - the highest price ever paid for a polo horse.^[39]
• In 2013, the world famous^[40] polo star Adolfo Cambiaso helped his team win the Argentine National Open, scoring nine goals in the 16-11 match. Two of those he scored atop a horse named Show Me—a clone, and the first to ride onto the Argentine pitch.^[41]

Mice

• Possibly the first cloned mammal was a mouse in 1986, in the Soviet Union.^[42] However, the cloning was done from an embryo cell, while the sheep Dolly in 1996 was cloned from an adult cell.
• The first mouse from adult cells, Cumulina, was born in 1997 at the University of Hawai'i at Mānoa in the laboratory of Ryuzo Yanagimachi using the Honolulu technique.
• In 2008 Japanese scientists created a cloned mouse from a dead mouse that had been frozen for 16 years. This was the first time a mammal had been cloned from frozen cells.^[43]

Mouflon

• A European mouflon lamb was the first cloned endangered species to live past infancy. Cloned 2001^[44]
• A cloned baby mouflon was born to a domestic sheep in an successful interspecies cloning of an endangered species in Iran in 2015.^[45]

Mule

• Idaho Gem (male, May 2003)^[46] was ranked third in the world among racing mules.^[47]
• Utah Pioneer (male, June 2003)
• Idaho Star (male, July 2003)

Pig

• 5 Scottish PPL piglets (Jose, Josúe, Juan, Amber and Jose) (March 5, 2000)^[48]
• Xena (female, August 2000)^[49]
• BGI, China was reported in January 2014 to be producing 500 cloned pigs a year, with a success rate of about 80%, to test new medicines.^[50]

Pyrenean ibex

In 2009, one clone was alive, but died seven minutes later, due to physical defects in the lungs. The Pyrenean ibex became the first taxon ever to come back from extinction, for a period of seven minutes in January 2009. This was a huge achievement for scientists and helped them believe that they could start bringing back extinct animals.^[51]

Rabbit

• ^[52] In France (March–April, 2003)^[53]

Rat

• Ralph (male, 2003)^[54]

Rhesus monkey

• Tetra (female, October 1999) by embryo splitting.^[55]
• Cloned embryos (November 2007) by transfer of DNA from adult cells.^[56]

Sheep

• From early embryonic cells by Steen Willadsen(1986). Megan and Morag cloned from differentiated embryonic cells in June 1995.
• Dolly (1996–2003), first cloned mammal from somatic cells. She had six lambs.^[57]
• Royana (2006) cloned in Royan Research Institute in Isfahan, Iran
• Oyalı^[58][59] and Zarife^[60] were cloned in November 2007 in Istanbul University in Istanbul, Turkey.

Water buffalo

The world's first water buffalo was cloned either in Beijing, China^[61] in 2005, or at National Dairy Research Institute in Karnal, India. In 2009 "Samrupa", became the world's first cloned water buffalo calf, who died a week later from a lung infection.^[62]

Wolf

• An endangered subspecies of gray wolf was cloned by South Korean scientists, including the controversial scientist Hwang Woo-Suk in 2005. The two female cloned wolves were housed in a zoo in South Korea for public view. The wolves were called Snuwolf and Snuwolffy, which were names taken from Seoul National University.^[63] Snuwolf died in 2009 from an infection.^[64]

References

• National Dairy Research Institute, Karnal, India
• Gallery of Cloned Animals — Guardian Unlimited
• 12 jersey cows that have been cloned in Knoxville, TN
• Iran's first cloned goat born in Isfahan
• http://www.biolreprod.org/content/early/2012/04/27/biolreprod.112.098855.full.pdf