SYNCRIP

Synaptotagmin binding, cytoplasmic RNA interacting protein

PDB rendering based on 2dgu.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2DGU, 2MXT

Identifiers

Symbols

SYNCRIP ; GRY-RBP; GRYRBP; HNRNPQ; HNRPQ1; NSAP1; PP68; hnRNP-Q

External IDs

MGI: 1891690 HomoloGene: 4648 GeneCards: SYNCRIP Gene

Gene ontology
Molecular function	• nucleotide binding • RNA binding • protein binding • poly(A) binding • poly(A) RNA binding
Cellular component	• nucleus • nucleoplasm • endoplasmic reticulum • membrane • ribonucleoprotein complex • CRD-mediated mRNA stability complex • catalytic step 2 spliceosome • histone pre-mRNA 3'end processing complex • GAIT complex
Biological process	• mRNA splicing, via spliceosome • osteoblast differentiation • RNA processing • RNA splicing • viral process • negative regulation of translation • CRD-mediated mRNA stabilization • cellular response to interferon-gamma
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
85.61 – 85.64 Mb

Chr 9:
88.45 – 88.48 Mb

PubMed search

Synaptotagmin binding, cytoplasmic RNA interacting protein, also known as Heterogeneous nuclear ribonucleoprotein Q is a protein that in humans is encoded by the SYNCRIP gene.^[1]^[2]^[3]

Interactions

SYNCRIP has been shown to interact with ACF,^[2]^[4] APOBEC1,^[2] SYT7^[5] and SYT9,^[5]

References

↑ Harris CE, Boden RA, Astell CR (January 1999). "A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice". J Virol 73 (1): 72–80. PMC 103810. PMID 9847309.
1 2 3 Lau PP, Chang BH, Chan L (May 2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome". Biochem Biophys Res Commun 282 (4): 977–83. doi:10.1006/bbrc.2001.4679. PMID 11352648.
↑ "Entrez Gene: SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein".
↑ Blanc, V; Navaratnam N; Henderson J O; Anant S; Kennedy S; Jarmuz A; Scott J; Davidson N O (March 2001). "Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing". J. Biol. Chem. (United States) 276 (13): 10272–83. doi:10.1074/jbc.M006435200. ISSN 0021-9258. PMID 11134005.
1 2 Mizutani, A; Fukuda M; Ibata K; Shiraishi Y; Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". J. Biol. Chem. (UNITED STATES) 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. ISSN 0021-9258. PMID 10734137.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Fu C, Chan AC (1997). "Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation". J. Biol. Chem. 272 (43): 27362–8. doi:10.1074/jbc.272.43.27362. PMID 9341187.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
Mizutani A, Fukuda M, Ibata K, et al. (2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". J. Biol. Chem. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
Grosset C, Chen CY, Xu N, et al. (2000). "A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex". Cell 103 (1): 29–40. doi:10.1016/S0092-8674(00)00102-1. PMID 11051545.
Blanc V, Navaratnam N, Henderson JO, et al. (2001). "Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing". J. Biol. Chem. 276 (13): 10272–83. doi:10.1074/jbc.M006435200. PMID 11134005.
Mourelatos Z, Abel L, Yong J, et al. (2001). "SMN interacts with a novel family of hnRNP and spliceosomal proteins". EMBO J. 20 (19): 5443–52. doi:10.1093/emboj/20.19.5443. PMC 125643. PMID 11574476.
Rossoll W, Kröning AK, Ohndorf UM, et al. (2002). "Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?". Hum. Mol. Genet. 11 (1): 93–105. doi:10.1093/hmg/11.1.93. PMID 11773003.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Hresko RC, Mueckler M (2002). "Identification of pp68 as the Tyrosine-phosphorylated Form of SYNCRIP/NSAP1. A cytoplasmic RNA-binding protein". J. Biol. Chem. 277 (28): 25233–8. doi:10.1074/jbc.M202556200. PMID 11994298.
Carty SM, Greenleaf AL (2003). "Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing". Mol. Cell Proteomics 1 (8): 598–610. doi:10.1074/mcp.M200029-MCP200. PMID 12376575.
Angenstein F, Evans AM, Settlage RE, et al. (2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons". J. Neurosci. 22 (20): 8827–37. PMID 12388589.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hinsby AM, Olsen JV, Bennett KL, Mann M (2003). "Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry". Mol. Cell Proteomics 2 (1): 29–36. doi:10.1074/mcp.M200075-MCP200. PMID 12601080.
Moraes KC, Quaresma AJ, Maehnss K, Kobarg J (2003). "Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D)". Biol. Chem. 384 (1): 25–37. doi:10.1515/BC.2003.004. PMID 12674497.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Kim JH, Paek KY, Ha SH, et al. (2004). "A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon". Mol. Cell. Biol. 24 (18): 7878–90. doi:10.1128/MCB.24.18.7878-7890.2004. PMC 515056. PMID 15340051.
Quaresma AJ, et al. (2009). "Human hnRNP Q re-localizes to cytoplasmic granules upon PMA, thapsigargin, arsenite and heat-shock treatments". Exp Cell Res. 315 (6): 968–80. doi:10.1016/j.yexcr.2009.01.012. PMID 19331829.
Moraes KCM, Quaresma AJ, Kobarg, J (2003). "Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D)". BIOLOGICAL CHEMISTRY 384 (1): 25–37. doi:10.1515/BC.2003.004. ISSN 1431-6730. PMID 12674497.

PDB gallery

2dgu: Solution structure of the RNA binding domain in Heterogeneous nuclear ribonucleoprotein Q

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SYNCRIP

Interactions

References

Further reading