SYBL1

Vesicle-associated membrane protein 7

PDB rendering based on 2dmw.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2DMW

Identifiers

Symbols

VAMP7 ; SYBL1; TI-VAMP; TIVAMP; VAMP-7

External IDs

OMIM: 300053 MGI: 1096399 HomoloGene: 4121 GeneCards: VAMP7 Gene

Gene ontology
Molecular function	• SNARE binding • SNAP receptor activity • protein binding • syntaxin binding
Cellular component	• cytoplasm • lysosomal membrane • endoplasmic reticulum membrane • Golgi apparatus • trans-Golgi network • plasma membrane • cell surface • membrane • integral component of membrane • lamellipodium • cell junction • secretory granule • transport vesicle membrane • secretory granule membrane • phagocytic vesicle membrane • platelet alpha granule • pseudopodium • SNARE complex • late endosome membrane • azurophil granule membrane • neuron projection • intracellular membrane-bounded organelle • apical part of cell • synapse • phagocytic vesicle • perinuclear region of cytoplasm • extracellular exosome
Biological process	• ER to Golgi vesicle-mediated transport • post-Golgi vesicle-mediated transport • vesicle fusion • phagocytosis, engulfment • endosome to lysosome transport • vesicle-mediated transport • calcium ion-dependent exocytosis • triglyceride transport • SNARE complex assembly • Golgi to plasma membrane protein transport • eosinophil degranulation • neutrophil degranulation • natural killer cell degranulation • vesicle transport along microtubule • vesicle fusion with Golgi apparatus • positive regulation of dendrite morphogenesis • membrane organization • autophagosome maturation • regulation of protein targeting to vacuolar membrane • positive regulation of histamine secretion by mast cell
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
155.88 – 155.94 Mb

Chr GL456233.1:
0.01 – 0.04 Mb

PubMed search

Vesicle-associated membrane protein 7 (VAMP-7) is a protein that in humans is encoded by the VAMP7 gene.^[1]^[2]^[3]

Function

VAMP-7 is a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. VAMP-7 localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes.^[3]

Interactions

SYBL1 has been shown to interact with SNAP23^[4]^[5] and AP3D1.^[4]

References

↑ D'Esposito M, Ciccodicola A, Gianfrancesco F, Esposito T, Flagiello L, Mazzarella R, Schlessinger D, D'Urso M (Jul 1996). "A synaptobrevin-like gene in the Xq28 pseudoautosomal region undergoes X inactivation". Nat. Genet. 13 (2): 227–9. doi:10.1038/ng0696-227. PMID 8640232.
↑ Filippini F, Rossi V, Galli T, Budillon A, D'Urso M, D'Esposito M (Jul 2001). "Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain". Trends Biochem. Sci. 26 (7): 407–9. doi:10.1016/S0968-0004(01)01861-8. PMID 11440841.
1 2 "Entrez Gene: SYBL1 synaptobrevin-like 1".
1 2 Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T (Jul 2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 9011–6. doi:10.1073/pnas.1431910100. PMC 166429. PMID 12853575.
↑ Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D (Jun 1998). "A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells". Mol. Biol. Cell 9 (6): 1437–48. doi:10.1091/mbc.9.6.1437. PMC 25366. PMID 9614185.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D (1998). "A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells". Mol. Biol. Cell 9 (6): 1437–48. doi:10.1091/mbc.9.6.1437. PMC 25366. PMID 9614185.
Advani RJ, Yang B, Prekeris R, Lee KC, Klumperman J, Scheller RH (1999). "VAMP-7 mediates vesicular transport from endosomes to lysosomes". J. Cell Biol. 146 (4): 765–76. doi:10.1083/jcb.146.4.765. PMC 2156136. PMID 10459012.
Matarazzo MR, Cuccurese M, Strazzullo M, Vacca M, Curci A, Miano MG, Cocchia M, Mercadante G, Torino A, D'Urso M, Ciccodicola A, D'Esposito M (1999). "Human and mouse SYBL1 gene structure and expression". Gene 240 (1): 233–8. doi:10.1016/S0378-1119(99)00375-3. PMID 10564831.
Ciccodicola A, D'Esposito M, Esposito T, Gianfrancesco F, Migliaccio C, Miano MG, Matarazzo MR, Vacca M, Franzè A, Cuccurese M, Cocchia M, Curci A, Terracciano A, Torino A, Cocchia S, Mercadante G, Pannone E, Archidiacono N, Rocchi M, Schlessinger D, D'Urso M (2000). "Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region". Hum. Mol. Genet. 9 (3): 395–401. doi:10.1093/hmg/9.3.395. PMID 10655549.
Ward DM, Pevsner J, Scullion MA, Vaughn M, Kaplan J (2000). "Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages". Mol. Biol. Cell 11 (7): 2327–33. doi:10.1091/mbc.11.7.2327. PMC 14922. PMID 10888671.
Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R (2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.
Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE (2001). "Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells". J. Biol. Chem. 276 (23): 19820–7. doi:10.1074/jbc.M010838200. PMID 11278762.
Antonin W, Fasshauer D, Becker S, Jahn R, Schneider TR (2002). "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs". Nat. Struct. Biol. 9 (2): 107–11. doi:10.1038/nsb746. PMID 11786915.
Müller DJ, Schulze TG, Jahnes E, Cichon S, Krauss H, Kesper K, Held T, Maier W, Propping P, Nöthen MM, Rietschel M (2002). "Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder". Am. J. Med. Genet. 114 (1): 74–8. doi:10.1002/ajmg.10115. PMID 11840509.
Bogdanovic A, Bennett N, Kieffer S, Louwagie M, Morio T, Garin J, Satre M, Bruckert F (2002). "Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum". Biochem. J. 368 (Pt 1): 29–39. doi:10.1042/BJ20020845. PMC 1222979. PMID 12175335.
Matarazzo MR, De Bonis ML, Gregory RI, Vacca M, Hansen RS, Mercadante G, D'Urso M, Feil R, D'Esposito M (2002). "Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes". Hum. Mol. Genet. 11 (25): 3191–8. doi:10.1093/hmg/11.25.3191. PMID 12444103.
Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T (2003). "A dual mechanism controlling the localization and function of exocytic v-SNAREs". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 9011–6. doi:10.1073/pnas.1431910100. PMC 166429. PMID 12853575.
Di Leva F, Ferrante MI, Demarchi F, Caravelli A, Matarazzo MR, Giacca M, D'Urso M, D'Esposito M, Franzé A (2004). "Human synaptobrevin-like 1 gene basal transcription is regulated through the interaction of selenocysteine tRNA gene transcription activating factor-zinc finger 143 factors with evolutionary conserved cis-elements". J. Biol. Chem. 279 (9): 7734–9. doi:10.1074/jbc.M308140200. PMID 14672948.
Rao SK, Huynh C, Proux-Gillardeaux V, Galli T, Andrews NW (2004). "Identification of SNAREs involved in synaptotagmin VII-regulated lysosomal exocytosis". J. Biol. Chem. 279 (19): 20471–9. doi:10.1074/jbc.M400798200. PMID 14993220.

PDB gallery

2dmw: Solution structure of the LONGIN domain of Synaptobrevin-like protein 1

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SYBL1

Function

Interactions

References

Further reading