STX4

Syntaxin 4

Identifiers

STX4 ; STX4A; p35-2

External IDs

OMIM: 186591 MGI: 893577 HomoloGene: 105435 GeneCards: STX4 Gene

Gene ontology
Molecular function	• SNARE binding • SNAP receptor activity • protein binding • sphingomyelin phosphodiesterase activator activity
Cellular component	• extracellular space • intracellular • endosome • vacuole • trans-Golgi network • cytosol • plasma membrane • synaptic vesicle • cell surface • endomembrane system • membrane • integral component of membrane • basolateral plasma membrane • lamellipodium • SNARE complex • myelin sheath adaxonal region • somatodendritic compartment • specific granule • dendritic spine • lateral loop • synapse • perinuclear region of cytoplasm • extracellular exosome
Biological process	• intracellular protein transport • exocytosis • post-Golgi vesicle-mediated transport • blood coagulation • positive regulation of cell proliferation • regulation of exocytosis • platelet activation • positive regulation of cell migration • synaptic vesicle fusion to presynaptic membrane • response to hydroperoxide • SNARE complex assembly • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of catalytic activity • positive regulation of eosinophil degranulation • positive regulation of cell adhesion • vesicle docking • organelle fusion • positive regulation of chemotaxis • positive regulation of immunoglobulin secretion • long-term synaptic potentiation • membrane organization • positive regulation of establishment of protein localization to plasma membrane • regulation of extrinsic apoptotic signaling pathway via death domain receptors • positive regulation of protein localization to plasma membrane • positive regulation of protein localization to cell surface
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
31.03 – 31.04 Mb

Chr 7:
127.82 – 127.85 Mb

PubMed search

Syntaxin-4 is a protein that in humans is encoded by the STX4 gene.^[1]^[2]^[3]

Interactions

STX4 has been shown to interact with:

NAPA,^[4]
RAB4A,^[5]
SNAP-25,^[6]^[7]^[8]^[9]
SNAP23,^[7]^[9]^[10]^[11]^[12]^[13]^[14]^[15]
STXBP1,^[6]^[16]
STXBP5,^[17]
Syntaxin binding protein 3,^[16]^[17]
TXLNB,^[18]
VAMP2,^[8]^[13]^[19]^[20]
VAMP3,^[4]^[10]^[13]^[21] and
Vesicle-associated membrane protein 8.^[13]^[21]

References

↑ Li H, Hodge DR, Pei GK, Seth A (Jun 1994). "Isolation and sequence analysis of the human syntaxin-encoding gene". Gene 143 (2): 303–4. doi:10.1016/0378-1119(94)90117-1. PMID 8206394.
↑ Low SH, Vasanji A, Nanduri J, He M, Sharma N, Koo M, Drazba J, Weimbs T (Feb 2006). "Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity". Molecular Biology of the Cell 17 (2): 977–89. doi:10.1091/mbc.E05-05-0462. PMC 1356605. PMID 16339081.
↑ "Entrez Gene: STX4 Syntaxin 4".
1 2 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
↑ Li L, Omata W, Kojima I, Shibata H (Feb 2001). "Direct interaction of Rab4 with syntaxin 4". The Journal of Biological Chemistry 276 (7): 5265–73. doi:10.1074/jbc.M003883200. PMID 11063739.
1 2 Hata Y, Südhof TC (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". The Journal of Biological Chemistry 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.
1 2 Ravichandran V, Chawla A, Roche PA (Jun 1996). "Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues". The Journal of Biological Chemistry 271 (23): 13300–3. doi:10.1074/jbc.271.23.13300. PMID 8663154.
1 2 Reed GL, Houng AK, Fitzgerald ML (Apr 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood 93 (8): 2617–26. PMID 10194441.
1 2 Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (Dec 1998). "Three novel proteins of the syntaxin/SNAP-25 family". The Journal of Biological Chemistry 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
1 2 Imai A, Nashida T, Yoshie S, Shimomura H (Aug 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Archives of Oral Biology 48 (8): 597–604. doi:10.1016/s0003-9969(03)00116-x. PMID 12828989.
↑ Li G, Alexander EA, Schwartz JH (May 2003). "Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis". The Journal of Biological Chemistry 278 (22): 19791–7. doi:10.1074/jbc.M212250200. PMID 12651853.
↑ Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M (May 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochemical and Biophysical Research Communications 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. PMID 9168999.
1 2 3 4 Paumet F, Le Mao J, Martin S, Galli T, David B, Blank U, Roa M (Jun 2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment". Journal of Immunology 164 (11): 5850–7. doi:10.4049/jimmunol.164.11.5850. PMID 10820264.
↑ Kawanishi M, Tamori Y, Okazawa H, Araki S, Shinoda H, Kasuga M (Mar 2000). "Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2". The Journal of Biological Chemistry 275 (11): 8240–7. doi:10.1074/jbc.275.11.8240. PMID 10713150.
↑ Freedman SJ, Song HK, Xu Y, Sun ZY, Eck MJ (Apr 2003). "Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain". The Journal of Biological Chemistry 278 (15): 13462–7. doi:10.1074/jbc.M210483200. PMID 12556468.
1 2 Schraw TD, Lemons PP, Dean WL, Whiteheart SW (Aug 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". The Biochemical Journal 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. PMC 1223584. PMID 12773094.
1 2 Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (Sep 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". The Journal of Biological Chemistry 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.
↑ Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (Jul 2004). "Identification and characterization of taxilin isoforms". Biochemical and Biophysical Research Communications 319 (3): 936–43. doi:10.1016/j.bbrc.2004.05.073. PMID 15184072.
↑ Mollinedo F, Martín-Martín B, Calafat J, Nabokina SM, Lazo PA (Jan 2003). "Role of vesicle-associated membrane protein-2, through Q-soluble N-ethylmaleimide-sensitive factor attachment protein receptor/R-soluble N-ethylmaleimide-sensitive factor attachment protein receptor interaction, in the exocytosis of specific and tertiary granules of human neutrophils". Journal of Immunology 170 (2): 1034–42. doi:10.4049/jimmunol.170.2.1034. PMID 12517971.
↑ Jagadish MN, Fernandez CS, Hewish DR, Macaulay SL, Gough KH, Grusovin J, Verkuylen A, Cosgrove L, Alafaci A, Frenkel MJ, Ward CW (Aug 1996). "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2". The Biochemical Journal 317 (3): 945–54. doi:10.1042/bj3170945. PMC 1217577. PMID 8760387.
1 2 Polgár J, Chung SH, Reed GL (Aug 2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion". Blood 100 (3): 1081–3. doi:10.1182/blood.v100.3.1081. PMID 12130530.

Bennett MK, García-Arrarás JE, Elferink LA, Peterson K, Fleming AM, Hazuka CD, Scheller RH (Sep 1993). "The syntaxin family of vesicular transport receptors". Cell 74 (5): 863–73. doi:10.1016/0092-8674(93)90466-4. PMID 7690687.
Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (Jun 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature 375 (6532): 594–9. doi:10.1038/375594a0. PMID 7791877.
Jagadish MN, Fernandez CS, Hewish DR, Macaulay SL, Gough KH, Grusovin J, Verkuylen A, Cosgrove L, Alafaci A, Frenkel MJ, Ward CW (Aug 1996). "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2". The Biochemical Journal 317 (Pt 3): 945–54. doi:10.1042/bj3170945. PMC 1217577. PMID 8760387.
Mandon B, Chou CL, Nielsen S, Knepper MA (Aug 1996). "Syntaxin-4 is localized to the apical plasma membrane of rat renal collecting duct cells: possible role in aquaporin-2 trafficking". The Journal of Clinical Investigation 98 (4): 906–13. doi:10.1172/JCI118873. PMC 507504. PMID 8770861.
Timmers KI, Clark AE, Omatsu-Kanbe M, Whiteheart SW, Bennett MK, Holman GD, Cushman SW (Dec 1996). "Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein". The Biochemical Journal 320 (Pt 2): 429–36. doi:10.1042/bj3200429. PMC 1217948. PMID 8973549.
Tellam JT, Macaulay SL, McIntosh S, Hewish DR, Ward CW, James DE (Mar 1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4". The Journal of Biological Chemistry 272 (10): 6179–86. doi:10.1074/jbc.272.10.6179. PMID 9045631.
Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M (May 1997). "Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c". Biochemical and Biophysical Research Communications 234 (1): 257–62. doi:10.1006/bbrc.1997.6560. PMID 9168999.
Inoue T, Nielsen S, Mandon B, Terris J, Kishore BK, Knepper MA (Nov 1998). "SNAP-23 in rat kidney: colocalization with aquaporin-2 in collecting duct vesicles". The American Journal of Physiology 275 (5 Pt 2): F752–60. PMID 9815132.
Reed GL, Houng AK, Fitzgerald ML (Apr 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood 93 (8): 2617–26. PMID 10194441.
Min J, Okada S, Kanzaki M, Elmendorf JS, Coker KJ, Ceresa BP, Syu LJ, Noda Y, Saltiel AR, Pessin JE (Jun 1999). "Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes". Molecular Cell 3 (6): 751–60. doi:10.1016/S1097-2765(01)80007-1. PMID 10394363.
Thomas DM, Ferguson GD, Herschman HR, Elferink LA (Jul 1999). "Functional and biochemical analysis of the C2 domains of synaptotagmin IV". Molecular Biology of the Cell 10 (7): 2285–95. doi:10.1091/mbc.10.7.2285. PMC 25443. PMID 10397765.
Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ (Nov 1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". International Journal of Cancer. Journal International Du Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
Paumet F, Le Mao J, Martin S, Galli T, David B, Blank U, Roa M (Jun 2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment". Journal of Immunology 164 (11): 5850–7. doi:10.4049/jimmunol.164.11.5850. PMID 10820264.
Li L, Omata W, Kojima I, Shibata H (Feb 2001). "Direct interaction of Rab4 with syntaxin 4". The Journal of Biological Chemistry 276 (7): 5265–73. doi:10.1074/jbc.M003883200. PMID 11063739.
Logan MR, Lacy P, Bablitz B, Moqbel R (Feb 2002). "Expression of eosinophil target SNAREs as potential cognate receptors for vesicle-associated membrane protein-2 in exocytosis". The Journal of Allergy and Clinical Immunology 109 (2): 299–306. doi:10.1067/mai.2002.121453. PMID 11842301.
Dent J, Kato K, Peng XR, Martinez C, Cattaneo M, Poujol C, Nurden P, Nurden A, Trimble WS, Ware J (Mar 2002). "A prototypic platelet septin and its participation in secretion". Proceedings of the National Academy of Sciences of the United States of America 99 (5): 3064–9. doi:10.1073/pnas.052715199. PMC 122473. PMID 11880646.
Perskvist N, Roberg K, Kulyté A, Stendahl O (Mar 2002). "Rab5a GTPase regulates fusion between pathogen-containing phagosomes and cytoplasmic organelles in human neutrophils". Journal of Cell Science 115 (Pt 6): 1321–30. PMID 11884531.
Polgár J, Chung SH, Reed GL (Aug 2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion". Blood 100 (3): 1081–3. doi:10.1182/blood.V100.3.1081. PMID 12130530.
Scales SJ, Hesser BA, Masuda ES, Scheller RH (Aug 2002). "Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly". The Journal of Biological Chemistry 277 (31): 28271–9. doi:10.1074/jbc.M204929200. PMID 12145319.

Membrane protein: vesicular transport proteins (TC 1F)

Synaptic vesicle

SNARE

Q-SNARE	SNAP25 SNAP29 Syntaxin STX1A STX1B STX2 STX3 STX4 STX5 STX6 STX7 STX8 STX10 STX11 STX12 STX16 STX17 STX18 STX19 Munc-18: STXBP1 STXBP2 STXBP3 STXBP4 STXBP5 STXBP6

R-SNARE	Synaptobrevin/VAMP: VAMP1 VAMP2 VAMP3

Synaptotagmin

SYT1
SYT2
SYT3
SYT4
SYT5
SYT6
SYT7
SYT8
SYT9
SYT10
SYT11
SYT12
SYT13
SYT14
SYT15
SYT16
SYT17

Other

Small GTPase: RAB3A

COPI

Coatomer
- COPA
- COPB1
- COPB2
- COPE
- COPG
- COPG2
- COPZ1
- COPZ2

Archain

Small GTPase: ARF

COPII

Vesicle formation: SEC23A

Small GTPase: SAR1A

RME/Clathrin

CLTA
CLTB
CLTC

Caveolae

Other/ungrouped

Vesicle formation

Adaptor protein complex 1:	AP1AR AP1B1 AP1G1 AP1G2 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3

Adaptor protein complex 2:	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1

Adaptor protein complex 3:	AP3B1 AP3B2 AP3D1 AP3M1 AP3M2 AP3S1 AP3S2

Adaptor protein complex 4:	AP4B1 AP4E1 AP4M1 AP4S1

LMAN1

LYST

BLOC-1:	DTNBP1 BLOC153

BLOC-2:	HPS3 HPS5 HPS6

BLOC-3:	HPS1 HPS4

Coats:	Retromer TIP47

Small GTPase

Dynamin
- DNM1
- DNM2
- DNM3

Other

Sorting nexins

SYNRG

See also vesicular transport protein disorders

This article is issued from Wikipedia - version of the Tuesday, January 05, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

STX4

Interactions

References

Further reading