ST7
See also ST6/ST7 microcontroller
| Suppression of tumorigenicity 7 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | ST7 ; ETS7q; FAM4A; FAM4A1; HELG; RAY1; SEN4; TSG7 | ||||||||||
| External IDs | OMIM: 600833 MGI: 1927450 HomoloGene: 10185 GeneCards: ST7 Gene | ||||||||||
| |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 7982 | 64213 | |||||||||
| Ensembl | ENSG00000004866 | ENSMUSG00000029534 | |||||||||
| UniProt | Q9NRC1 | Q99M96 | |||||||||
| RefSeq (mRNA) | NM_018412 | NM_001083315 | |||||||||
| RefSeq (protein) | NP_060882 | NP_001076784 | |||||||||
| Location (UCSC) |
Chr 7: 116.95 – 117.23 Mb |
Chr 6: 17.69 – 17.94 Mb | |||||||||
| PubMed search | |||||||||||
Suppressor of tumorigenicity protein 7 is a protein that in humans is encoded by the ST7 gene.[1][2][3] ST7 orthologs [4] have been identified in all mammals for which complete genome data are available.
The gene for this product maps to a region on human chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described.[3]
Interactions
ST7 has been shown to interact with ITGB1BP3[5] and GNB2L1.[5]
References
- ↑ Ogata T, Ayusawa D, Namba M, Takahashi E, Oshimura M, Oishi M (Oct 1993). "Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1". Mol Cell Biol 13 (10): 6036–43. PMC 364663. PMID 8105370.
- ↑ Zenklusen JC, Rodriguez LV, LaCava M, Wang Z, Goldstein LS, Conti CJ (Feb 1997). "Novel susceptibility locus for mouse hepatomas: evidence for a conserved tumor suppressor gene". Genome Res 6 (11): 1070–6. doi:10.1101/gr.6.11.1070. PMID 8938430.
- 1 2 "Entrez Gene: ST7 suppression of tumorigenicity 7".
- ↑ "OrthoMaM phylogenetic marker: ST7 coding sequence".
- 1 2 Battle, Michele A; Maher Veronica M; McCormick J Justin (Jun 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry (United States) 42 (24): 7270–82. doi:10.1021/bi034081y. ISSN 0006-2960. PMID 12809483.
Further reading
- Zenklusen JC, Weitzel JN, Ball HG, Conti CJ (1995). "Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene.". Oncogene 11 (2): 359–63. PMID 7624150.
- Zenklusen JC, Thompson JC, Troncoso P, et al. (1995). "Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1.". Cancer Res. 54 (24): 6370–3. PMID 7987830.
- Zenklusen JC, Bièche I, Lidereau R, Conti CJ (1995). "(C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer.". Proc. Natl. Acad. Sci. U.S.A. 91 (25): 12155–8. doi:10.1073/pnas.91.25.12155. PMC 45395. PMID 7991599.
- Folstein SE, Mankoski RE (2000). "Chromosome 7q: where autism meets language disorder?". Am. J. Hum. Genet. 67 (2): 278–81. doi:10.1086/303034. PMC 1287175. PMID 10889044.
- Vincent JB, Herbrick JA, Gurling HM, et al. (2000). "Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual.". Am. J. Hum. Genet. 67 (2): 510–4. doi:10.1086/303005. PMC 1287197. PMID 10889047.
- Zenklusen JC, Conti CJ, Green ED (2001). "Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31.". Nat. Genet. 27 (4): 392–8. doi:10.1038/86891. PMID 11279520.
- Brown VL, Proby CM, Barnes DM, Kelsell DP (2002). "Lack of mutations within ST7 gene in tumour-derived cell lines and primary epithelial tumours.". Br. J. Cancer 87 (2): 208–11. doi:10.1038/sj.bjc.6600418. PMC 2376116. PMID 12107844.
- Vincent JB, Petek E, Thevarkunnel S, et al. (2003). "The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system.". Genomics 80 (3): 283–94. doi:10.1006/geno.2002.6835. PMID 12213198.
- Dong SM, Sidransky D (2002). "Absence of ST7 gene alterations in human cancer.". Clin. Cancer Res. 8 (9): 2939–41. PMID 12231539.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wang S, Mori Y, Sato F, et al. (2003). "An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma.". Oncogene 22 (3): 467–70. doi:10.1038/sj.onc.1206125. PMID 12545169.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Battle MA, Maher VM, McCormick JJ (2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways.". Biochemistry 42 (24): 7270–82. doi:10.1021/bi034081y. PMID 12809483.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- Sivasundaram K, Suzuki H, Seto M, Hosokawa Y (2004). "Mutational analysis of the ST7 gene in human myeloid tumor cell lines.". Oncol. Rep. 10 (6): 1737–9. doi:10.3892/or.10.6.1737. PMID 14534688.
- Lu C, Xu HM, Ren Q, et al. (2004). "Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC.". World J. Gastroenterol. 9 (12): 2662–5. PMID 14669308.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Liu J, Gough J, Rost B (2006). "Distinguishing protein-coding from non-coding RNAs through support vector machines.". PLoS Genet. 2 (4): e29. doi:10.1371/journal.pgen.0020029. PMC 1449884. PMID 16683024.
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