SPRY4
| Sprouty RTK signaling antagonist 4 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SPRY4 ; HH17 | ||||||||||||
| External IDs | OMIM: 607984 MGI: 1345144 HomoloGene: 8042 GeneCards: SPRY4 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 81848 | 24066 | |||||||||||
| Ensembl | ENSG00000187678 | ENSMUSG00000024427 | |||||||||||
| UniProt | Q9C004 | Q9WTP2 | |||||||||||
| RefSeq (mRNA) | NM_001127496 | NM_011898 | |||||||||||
| RefSeq (protein) | NP_001120968 | NP_036028 | |||||||||||
| Location (UCSC) |
Chr 5: 142.31 – 142.33 Mb |
Chr 18: 38.59 – 38.6 Mb | |||||||||||
| PubMed search | |||||||||||||
Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.[1][2]
Function
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).[supplied by OMIM][2]
See also
Interactions
SPRY4 has been shown to interact with TESK1.[3]
References
- ↑ Katoh Y, Katoh M (Mar 2006). "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells". International Journal of Molecular Medicine 17 (3): 529–32. doi:10.3892/ijmm.17.3.529. PMID 16465403.
- 1 2 "Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila)".
- ↑ Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry / FEBS 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.
Further reading
- Zaharieva I, Georgieva L, Nikolov I, Kirov G, Owen MJ, O'Donovan MC, Toncheva D (2008). "Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping". BMC Psychiatry 8: 11. doi:10.1186/1471-244X-8-11. PMC 2268687. PMID 18298822.
- Cabrita MA, Jäggi F, Widjaja SP, Christofori G (Sep 2006). "A functional interaction between sprouty proteins and caveolin-1". The Journal of Biological Chemistry 281 (39): 29201–12. doi:10.1074/jbc.M603921200. PMID 16877379.
- Wang J, Thompson B, Ren C, Ittmann M, Kwabi-Addo B (May 2006). "Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer". The Prostate 66 (6): 613–24. doi:10.1002/pros.20353. PMID 16388505.
- Ding W, Bellusci S, Shi W, Warburton D (Jul 2004). "Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis". American Journal of Physiology. Lung Cellular and Molecular Physiology 287 (1): L52–9. doi:10.1152/ajplung.00430.2003. PMID 14977631.
- Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A (May 2003). "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1". Nature Cell Biology 5 (5): 427–32. doi:10.1038/ncb978. PMID 12717443.
- Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry / FEBS 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.
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