Surfactant protein C
| Surfactant protein C, N terminal propeptide | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
Pulmonary surfactant-associated polypeptide SP-C Protein | |||||||||
| Identifiers | |||||||||
| Symbol | SP_C-Propep | ||||||||
| Pfam | PF08999 | ||||||||
| InterPro | IPR001729 | ||||||||
| PROSITE | PDOC00298 | ||||||||
| OPM superfamily | 75 | ||||||||
| OPM protein | 1spf | ||||||||
| |||||||||
| surfactant, pulmonary-associated protein C | |
|---|---|
| Identifiers | |
| Symbol | SFTPC |
| Alt. symbols | SFTP2 |
| Entrez | 6440 |
| HUGO | 10802 |
| OMIM | 178620 |
| RefSeq | NM_003018 |
| UniProt | P11686 |
| Other data | |
| Locus | Chr. 8 p21 |
Surfactant proteins C are a family of related pulmonary surfactant proteins.
The propeptide of human protein from this family has an N-terminal alpha-helical segment whose suggested function was stabilization of the protein structure, since the latter can irreversibly transform from its native alpha-helical structure to beta-sheet aggregates and form amyloid fibrils. The correct intracellular trafficking of proSP-C has also been reported to depend on the propeptide.[1]
References
- ↑ Li J, Liepinsh E, Almlén A, Thyberg J, Curstedt T, Jörnvall H, Johansson J (March 2006). "Structure and influence on stability and activity of the N-terminal propeptide part of lung surfactant protein C". FEBS J. 273 (5): 926–35. doi:10.1111/j.1742-4658.2006.05124.x. PMID 16478467.
External links
- Pulmonary Surfactant-Associated Protein C at the US National Library of Medicine Medical Subject Headings (MeSH)
- Hane F. "Surfactant Protein C (SP-C) Mini- Review" (PDF). www.physics.uwaterloo.ca. Retrieved 2009-03-08.
Covers structure, function, pathologies and synthesis of SP-C
This article incorporates text from the public domain Pfam and InterPro IPR015091
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