SNAI2

Snail family zinc finger 2

Identifiers

SNAI2 ; SLUG; SLUGH1; SNAIL2; WS2D

External IDs

OMIM: 602150 MGI: 1096393 HomoloGene: 31127 GeneCards: SNAI2 Gene

Gene ontology
Molecular function	• transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • protein binding • sequence-specific DNA binding • metal ion binding
Cellular component	• nuclear chromatin • nucleus • cytoplasm
Biological process	• negative regulation of transcription from RNA polymerase II promoter • osteoblast differentiation • epithelial to mesenchymal transition • epithelial to mesenchymal transition involved in endocardial cushion formation • cell migration involved in endocardial cushion formation • transcription from RNA polymerase II promoter • negative regulation of cell adhesion involved in substrate-bound cell migration • Notch signaling pathway • sensory perception of sound • negative regulation of keratinocyte proliferation • negative regulation of vitamin D biosynthetic process • neural crest cell development • positive regulation of cell migration • negative regulation of chondrocyte differentiation • regulation of chemokine production • negative regulation of cell adhesion mediated by integrin • positive regulation of histone acetylation • negative regulation of catenin import into nucleus • desmosome disassembly • pigmentation • negative regulation of DNA damage response, signal transduction by p53 class mediator • cellular response to fibroblast growth factor stimulus • positive regulation of fat cell differentiation • regulation of osteoblast differentiation • white fat cell differentiation • palate development • canonical Wnt signaling pathway • epithelium development • cartilage morphogenesis • regulation of branching involved in salivary gland morphogenesis • negative regulation of vitamin D receptor signaling pathway • cellular response to epidermal growth factor stimulus • cellular response to ionizing radiation • negative regulation of canonical Wnt signaling pathway • negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage • negative regulation of stem cell proliferation • regulation of bicellular tight junction assembly • negative regulation of anoikis • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
48.92 – 48.92 Mb

Chr 16:
14.71 – 14.71 Mb

PubMed search

Zinc finger protein SNAI2 is a protein that in humans is encoded by the SNAI2 gene.^[1]^[2]^[3]

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporadic cases of neural tube defects.^[3]

References

↑ Rhim H, Savagner P, Thibaudeau G, Thiery JP, Pavan WJ (Jan 1998). "Localization of a neural crest transcription factor, Slug, to mouse chromosome 16 and human chromosome 8". Mamm Genome 8 (11): 872–3. doi:10.1007/s003359900601. PMID 9337409.
↑ Cohen ME, Yin M, Paznekas WA, Schertzer M, Wood S, Jabs EW (Oct 1998). "Human SLUG gene organization, expression, and chromosome map location on 8q". Genomics 51 (3): 468–71. doi:10.1006/geno.1998.5367. PMID 9721220.
1 2 "Entrez Gene: SNAI2 snail homolog 2 (Drosophila)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Savagner P, Yamada KM, Thiery JP (1997). "The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition.". J. Cell Biol. 137 (6): 1403–19. doi:10.1083/jcb.137.6.1403. PMC 2132541. PMID 9182671.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Stegmann K, Boecker J, Kosan C, et al. (1999). "Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region.". Mutat. Res. 406 (2-4): 63–9. doi:10.1016/S1383-5726(99)00002-3. PMID 10479723.
Inukai T, Inoue A, Kurosawa H, et al. (1999). "SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein.". Mol. Cell 4 (3): 343–52. doi:10.1016/S1097-2765(00)80336-6. PMID 10518215.
Hemavathy K, Guru SC, Harris J, et al. (2000). "Human Slug is a repressor that localizes to sites of active transcription.". Mol. Cell. Biol. 20 (14): 5087–95. doi:10.1128/MCB.20.14.5087-5095.2000. PMC 85958. PMID 10866665.
Hajra KM, Chen DY, Fearon ER (2002). "The SLUG zinc-finger protein represses E-cadherin in breast cancer.". Cancer Res. 62 (6): 1613–8. PMID 11912130.
Sánchez-Martín M, Rodríguez-García A, Pérez-Losada J, et al. (2003). "SLUG (SNAI2) deletions in patients with Waardenburg disease.". Hum. Mol. Genet. 11 (25): 3231–6. doi:10.1093/hmg/11.25.3231. PMID 12444107.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kajita M, McClinic KN, Wade PA (2004). "Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress.". Mol. Cell. Biol. 24 (17): 7559–66. doi:10.1128/MCB.24.17.7559-7566.2004. PMC 506998. PMID 15314165.
Catalano A, Rodilossi S, Rippo MR, et al. (2004). "Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells.". J. Biol. Chem. 279 (45): 46706–14. doi:10.1074/jbc.M406696200. PMID 15337769.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Uchikado Y, Natsugoe S, Okumura H, et al. (2005). "Slug Expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma.". Clin. Cancer Res. 11 (3): 1174–80. PMID 15709186.
Tripathi MK, Misra S, Khedkar SV, et al. (2005). "Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells.". J. Biol. Chem. 280 (17): 17163–71. doi:10.1074/jbc.M501375200. PMC 3092429. PMID 15734731.
Tripathi MK, Misra S, Chaudhuri G (2005). "Negative regulation of the expressions of cytokeratins 8 and 19 by SLUG repressor protein in human breast cells.". Biochem. Biophys. Res. Commun. 329 (2): 508–15. doi:10.1016/j.bbrc.2005.02.006. PMC 3086003. PMID 15737616.
Moody SE, Perez D, Pan TC, et al. (2005). "The transcriptional repressor Snail promotes mammary tumor recurrence.". Cancer Cell 8 (3): 197–209. doi:10.1016/j.ccr.2005.07.009. PMID 16169465.
Chen M, Chen LM, Chai KX (2006). "Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG.". Prostate 66 (9): 911–20. doi:10.1002/pros.20325. PMID 16541421.
Turner FE, Broad S, Khanim FL, et al. (2006). "Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes.". J. Biol. Chem. 281 (30): 21321–31. doi:10.1074/jbc.M509731200. PMID 16707493.

This article is issued from Wikipedia - version of the Wednesday, September 02, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

SNAI2

References

Further reading