SLC26A6
Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene.[1][2][3] It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.[4]
This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.[3]
See also
References
- ↑ Lohi H, Kujala M, Kerkela E, Saarialho-Kere U, Kestila M, Kere J (Jan 2001). "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger". Genomics 70 (1): 102–12. doi:10.1006/geno.2000.6355. PMID 11087667.
- ↑ Waldegger S, Moschen I, Ramirez A, Smith RJ, Ayadi H, Lang F, Kubisch C (Mar 2001). "Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family". Genomics 72 (1): 43–50. doi:10.1006/geno.2000.6445. PMID 11247665.
- 1 2 "Entrez Gene: SLC26A6 solute carrier family 26, member 6".
- ↑ Wang, Zhaohui; Tong Wang; Snezana Petrovic; Biguang Tuo; Brigitte Riederer; Sharon Barone; John N. Lorenz; Ursula Seidler; Peter S. Aronson; Manoocher Soleimani (April 2005). "Renal and intestinal transport defects in Slc26a6-null mice". American Journal of Physiology. Cell Physiology. 4 288: C957–C965. doi:10.1152/ajpcell.00505.2004. PMID 15574486.
Further reading
- Markovich D (2001). "Physiological roles and regulation of mammalian sulfate transporters.". Physiol. Rev. 81 (4): 1499–533. PMID 11581495.
- Ignatovich O, Tomlinson IM, Popov AV, et al. (2000). "Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire.". J. Mol. Biol. 294 (2): 457–65. doi:10.1006/jmbi.1999.3243. PMID 10610771.
- Xie Q, Welch R, Mercado A, et al. (2002). "Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1.". Am. J. Physiol. Renal Physiol. 283 (4): F826–38. doi:10.1152/ajprenal.00079.2002. PMID 12217875.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Chernova MN, Jiang L, Friedman DJ, et al. (2005). "Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity.". J. Biol. Chem. 280 (9): 8564–80. doi:10.1074/jbc.M411703200. PMID 15548529.
- Kujala M, Tienari J, Lohi H, et al. (2006). "SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney.". Nephron Exp. Nephrol. 101 (2): e50–8. doi:10.1159/000086345. PMID 15956810.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Shcheynikov N, Wang Y, Park M, et al. (2006). "Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6.". J. Gen. Physiol. 127 (5): 511–24. doi:10.1085/jgp.200509392. PMC 2151520. PMID 16606687.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Alper SL, Stewart AK, Chernova MN, et al. (2007). "Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides.". Novartis Found. Symp. 273: 107–19; discussion 119–25, 261–4. doi:10.1002/0470029579.ch8. PMID 17120764.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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