SIVA1

SIVA1, apoptosis-inducing factor

Identifiers

SIVA1 ; CD27BP; SIVA; Siva-1; Siva-2

External IDs

OMIM: 605567 MGI: 1353606 HomoloGene: 4692 GeneCards: SIVA1 Gene

Gene ontology
Molecular function	• virus receptor activity • CD27 receptor binding • protein binding • zinc ion binding • metal ion binding
Cellular component	• nucleus • nucleoplasm • cytoplasm • mitochondrion
Biological process	• activation-induced cell death of T cells • negative regulation of NF-kappaB transcription factor activity • viral entry into host cell • extrinsic apoptotic signaling pathway • intrinsic apoptotic signaling pathway • positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
104.75 – 104.77 Mb

Chr 12:
112.64 – 112.65 Mb

PubMed search

Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene.^[1]^[2]

This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.^[2]

Interactions

SIVA1 has been shown to interact with CD27.^[1]

References

1 2 Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman SF (Jul 1997). "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein". Proc Natl Acad Sci U S A 94 (12): 6346–51. doi:10.1073/pnas.94.12.6346. PMC 21052. PMID 9177220.
1 2 "Entrez Gene: SIVA1 SIVA1, apoptosis-inducing factor".

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Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Henke A, Launhardt H, Klement K, et al. (2000). "Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva". J. Virol. 74 (9): 4284–90. doi:10.1128/JVI.74.9.4284-4290.2000. PMC 111945. PMID 10756043.
Cao C, Ren X, Kharbanda S, et al. (2001). "The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress". J. Biol. Chem. 276 (15): 11465–8. doi:10.1074/jbc.C100050200. PMID 11278261.
Henke A, Nestler M, Strunze S, et al. (2001). "The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva". Virology 289 (1): 15–22. doi:10.1006/viro.2001.1082. PMID 11601913.
Held-Feindt J, Mentlein R (2002). "CD70/CD27 ligand, a member of the TNF family, is expressed in human brain tumors". Int. J. Cancer 98 (3): 352–6. doi:10.1002/ijc.10207. PMID 11920585.
Xue L, Chu F, Cheng Y, et al. (2002). "Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6925–30. doi:10.1073/pnas.102182299. PMC 124505. PMID 12011449.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Spinicelli S, Nocentini G, Ronchetti S, et al. (2003). "GITR interacts with the pro-apoptotic protein Siva and induces apoptosis". Cell Death Differ. 9 (12): 1382–4. doi:10.1038/sj.cdd.4401140. PMID 12478477.
Chu F, Borthakur A, Sun X, et al. (2004). "The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis". Apoptosis 9 (1): 83–95. doi:10.1023/B:APPT.0000012125.01799.4c. PMID 14739602.
Py B, Slomianny C, Auberger P, et al. (2004). "Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway". J. Immunol. 172 (7): 4008–17. doi:10.4049/jimmunol.172.7.4008. PMID 15034012.
Fortin A, MacLaurin JG, Arbour N, et al. (2004). "The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1". J. Biol. Chem. 279 (27): 28706–14. doi:10.1074/jbc.M400376200. PMID 15105421.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Chu F, Barkinge J, Hawkins S, et al. (2005). "Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells: effect of elevated levels of BCL-2". Cancer Res. 65 (12): 5301–9. doi:10.1158/0008-5472.CAN-04-3270. PMID 15958577.
Gudi R, Barkinge J, Hawkins S, et al. (2006). "Siva-1 negatively regulates NF-kappaB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD)". Oncogene 25 (24): 3458–62. doi:10.1038/sj.onc.1209381. PMID 16491128.
Nestler M, Martin U, Hortschansky P, et al. (2006). "The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22". Mol. Cell. Biochem. 287 (1–2): 147–55. doi:10.1007/s11010-005-9082-6. PMID 16683188.
Severino A, Abbruzzese C, Manente L, et al. (2007). "Human papillomavirus-16 E7 interacts with Siva-1 and modulates apoptosis in HaCaT human immortalized keratinocytes". J. Cell. Physiol. 212 (1): 118–25. doi:10.1002/jcp.21011. PMID 17348035.

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SIVA1

Interactions

See also

References

Further reading