SH2D3A
| SH2 domain containing 3A | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | SH2D3A ; NSP1 | ||||||||||||
| External IDs | OMIM: 604721 HomoloGene: 48351 GeneCards: SH2D3A Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10045 | n/a | |||||||||||
| Ensembl | ENSG00000125731 | n/a | |||||||||||
| UniProt | Q9BRG2 | n/a | |||||||||||
| RefSeq (mRNA) | NM_005490 | n/a | |||||||||||
| RefSeq (protein) | NP_005481 | n/a | |||||||||||
| Location (UCSC) |
Chr 19: 6.75 – 6.77 Mb | n/a | |||||||||||
| PubMed search | n/a | ||||||||||||
SH2 domain-containing protein 3A is a protein that in humans is encoded by the SH2D3A gene.[1][2]
Interactions
SH2D3A has been shown to interact with Epidermal growth factor receptor.[1]
References
- 1 2 Lu Y, Brush J, Stewart TA (Apr 1999). "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway". The Journal of Biological Chemistry 274 (15): 10047–52. doi:10.1074/jbc.274.15.10047. PMID 10187783.
- ↑ "Entrez Gene: SH2D3A SH2 domain containing 3A".
Further reading
- Near RI, Zhang Y, Makkinje A, Vanden Borre P, Lerner A (Sep 2007). "AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology". Journal of Cellular Physiology 212 (3): 655–65. doi:10.1002/jcp.21059. PMC 2640322. PMID 17427198.
- Vervoort VS, Roselli S, Oshima RG, Pasquale EB (Apr 2007). "Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling". Gene 391 (1-2): 161–70. doi:10.1016/j.gene.2006.12.016. PMC 1876674. PMID 17270363.
- Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
External links
- SH2D3A human gene location in the UCSC Genome Browser.
- SH2D3A human gene details in the UCSC Genome Browser.
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