Protein C inhibitor

Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

PDB rendering based on 1lq8.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1LQ8, 1PAI, 2HI9, 2OL2, 2PAI, 3DY0

Identifiers

Symbols

SERPINA5 ; PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI

External IDs

OMIM: 601841 MGI: 107817 HomoloGene: 20159 GeneCards: SERPINA5 Gene

Gene ontology
Molecular function	• retinoic acid binding • protease binding • serine-type endopeptidase inhibitor activity • protein binding • glycosaminoglycan binding • heparin binding • phosphatidylcholine binding • acrosin binding
Cellular component	• acrosomal membrane • extracellular region • extracellular space • external side of plasma membrane • membrane • platelet alpha granule • platelet dense tubular network • protein C inhibitor-TMPRSS7 complex • protein C inhibitor-TMPRSS11E complex • protein C inhibitor-PLAT complex • protein C inhibitor-PLAU complex • protein C inhibitor-thrombin complex • protein C inhibitor-KLK3 complex • protein C inhibitor-plasma kallikrein complex • protein complex • extracellular exosome • protein C inhibitor-coagulation factor V complex • protein C inhibitor-coagulation factor Xa complex • protein C inhibitor-coagulation factor XI complex
Biological process	• lipid transport • spermatogenesis • fusion of sperm to egg plasma membrane • blood coagulation • negative regulation of endopeptidase activity • negative regulation of hydrolase activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
94.56 – 94.59 Mb

Chr 12:
104.1 – 104.11 Mb

PubMed search

Protein C inhibitor (PCI, SERPINA5) is a serine protease inhibitor (serpin) which limits the activity of protein C (an anticoagulant).

An N-terminal fragment of PCI is a possible serum biomarker for prostate cancer.^[1]

Protein C inhibitor is activated by heparin against thrombin.^[2]

Interactions

Protein C inhibitor has been shown to interact with prostate specific antigen,^[3]^[4] protein C^[5]^[6] and PLAU.^[5]^[7]

Suzuki K, Hayashi T (2000). "cis-elements required for expression of human protein C inhibitor gene in HepG2 cells and its androgen-dependent expression in rat reproductive organs.". Semin. Thromb. Hemost. 26 (1): 75–83. doi:10.1055/s-2000-9807. PMID 10805286.
Yasuda T, Nadano D, Iida R, et al. (1992). "Discovery of a genetic polymorphism of human plasma protein C inhibitor (PCI): genetic survey utilizing isoelectric focusing followed by immunoblotting, immunological and biochemical characterization.". Hum. Genet. 89 (3): 265–9. doi:10.1007/BF00220537. PMID 1318261.
Laurell M, Christensson A, Abrahamsson PA, et al. (1992). "Protein C inhibitor in human body fluids. Seminal plasma is rich in inhibitor antigen deriving from cells throughout the male reproductive system.". J. Clin. Invest. 89 (4): 1094–101. doi:10.1172/JCI115689. PMC 442965. PMID 1372913.
Meijers JC, Chung DW (1991). "Organization of the gene coding for human protein C inhibitor (plasminogen activator inhibitor-3). Assignment of the gene to chromosome 14.". J. Biol. Chem. 266 (23): 15028–34. PMID 1714450.
Kuhn LA, Griffin JH, Fisher CL, et al. (1990). "Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor.". Proc. Natl. Acad. Sci. U.S.A. 87 (21): 8506–10. doi:10.1073/pnas.87.21.8506. PMC 54985. PMID 2172989.
Meijers JC, Chung DW (1990). "Evidence for a glycine residue at position 316 in human protein C inhibitor.". Thromb. Res. 59 (2): 389–93. doi:10.1016/0049-3848(90)90142-Y. PMID 2173165.
España F, Berrettini M, Griffin JH (1989). "Purification and characterization of plasma protein C inhibitor.". Thromb. Res. 55 (3): 369–84. doi:10.1016/0049-3848(89)90069-8. PMID 2551064.
Laurell M, Stenflo J (1990). "Protein C inhibitor from human plasma: characterization of native and cleaved inhibitor and demonstration of inhibitor complexes with plasma kallikrein.". Thromb. Haemost. 62 (3): 885–91. PMID 2556811.
Geiger M, Huber K, Wojta J, et al. (1989). "Complex formation between urokinase and plasma protein C inhibitor in vitro and in vivo.". Blood 74 (2): 722–8. PMID 2752144.
Suzuki K, Deyashiki Y, Nishioka J, et al. (1987). "Characterization of a cDNA for human protein C inhibitor. A new member of the plasma serine protease inhibitor superfamily.". J. Biol. Chem. 262 (2): 611–6. PMID 3027058.
Suzuki K, Nishioka J, Hashimoto S (1983). "Protein C inhibitor. Purification from human plasma and characterization.". J. Biol. Chem. 258 (1): 163–8. PMID 6294098.
Christensson A, Lilja H (1994). "Complex formation between protein C inhibitor and prostate-specific antigen in vitro and in human semen.". Eur. J. Biochem. 220 (1): 45–53. doi:10.1111/j.1432-1033.1994.tb18597.x. PMID 7509746.
Zheng X, Geiger M, Ecke S, et al. (1994). "Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa.". Am. J. Physiol. 267 (2 Pt 1): C466–72. PMID 7521127.
Radtke KP, Fernández JA, Greengard JS, et al. (1994). "Protein C inhibitor is expressed in tubular cells of human kidney.". J. Clin. Invest. 94 (5): 2117–24. doi:10.1172/JCI117566. PMC 294656. PMID 7525654.
Hayashi S (1994). "Urinary protein C inhibitor binding region in the B beta-chain of human fibrinogen.". Blood Coagul. Fibrinolysis 4 (6): 921–6. doi:10.1097/00001721-199304060-00009. PMID 8148485.
Hayashi T, Suzuki K (1994). "Gene organization of human protein C inhibitor, a member of SERPIN family proteins encoded in five exons.". Int. J. Hematol. 58 (3): 213–24. PMID 8148499.
Billingsley GD, Walter MA, Hammond GL, Cox DW (1993). "Physical mapping of four serpin genes: alpha 1-antitrypsin, alpha 1-antichymotrypsin, corticosteroid-binding globulin, and protein C inhibitor, within a 280-kb region on chromosome I4q32.1.". Am. J. Hum. Genet. 52 (2): 343–53. PMC 1682208. PMID 8381582.
Hayashi S, Yamada K (1993). "Binding of urinary protein C inhibitor to fibrin(ogen) and its binding mechanism.". Blood Coagul. Fibrinolysis 4 (1): 153–8. doi:10.1097/00001721-199304010-00027. PMID 8384496.
Moore A, Penfold LM, Johnson JL, et al. (1993). "Human sperm-egg binding is inhibited by peptides corresponding to core region of an acrosomal serine protease inhibitor.". Mol. Reprod. Dev. 34 (3): 280–91. doi:10.1002/mrd.1080340308. PMID 8471250.
Hayashi S, Wakizaka A (1996). "Urinary protein C inhibitor binding region in the A alpha-chain of human fibrinogen.". Blood Coagul. Fibrinolysis 6 (5): 382–7. doi:10.1097/00001721-199507000-00003. PMID 8589203.

PDB gallery

1lq8: Crystal structure of cleaved protein C inhibitor

2hi9: Crystal Structure of human native protein C inhibitor

2ol2: High Resolution Structure of Native PCI in Space Group P21

References

↑ "Predicting Prostate Cancer Biochemical Recurrence Using a Panel of Serum Proteomic Biomarkers".
↑ Huntington, JA (Jun 2013). "Thrombin inhibition by the serpins.". Journal of thrombosis and haemostasis : JTH. 11 Suppl 1: 254–64. doi:10.1111/jth.12252. PMID 23809129.
↑ Christensson, A; Lilja H (February 1994). "Complex formation between protein C inhibitor and prostate-specific antigen in vitro and in human semen". Eur. J. Biochem. (Germany) 220 (1): 45–53. doi:10.1111/j.1432-1033.1994.tb18597.x. ISSN 0014-2956. PMID 7509746.
↑ Kise, H; Nishioka J; Kawamura J; Suzuki K (May 1996). "Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor". Eur. J. Biochem. (Germany) 238 (1): 88–96. doi:10.1111/j.1432-1033.1996.0088q.x. ISSN 0014-2956. PMID 8665956.
1 2 España, F; Berrettini M; Griffin J H (August 1989). "Purification and characterization of plasma protein C inhibitor". Thromb. Res. (United States) 55 (3): 369–84. doi:10.1016/0049-3848(89)90069-8. ISSN 0049-3848. PMID 2551064.
↑ Strandberg, K; Kjellberg M; Erb E M; Persson U; Mosher D F; Villoutreix B O; Stenflo J (December 2000). "Activated protein C-protein C inhibitor complex formation: characterization of a neoepitope provides evidence for extensive insertion of the reactive center loop". Biochemistry (UNITED STATES) 39 (51): 15713–20. doi:10.1021/bi001640h. ISSN 0006-2960. PMID 11123896.
↑ Geiger, M; Huber K; Wojta J; Stingl L; Espana F; Griffin J H; Binder B R (August 1989). "Complex formation between urokinase and plasma protein C inhibitor in vitro and in vivo". Blood (United States) 74 (2): 722–8. ISSN 0006-4971. PMID 2752144.

External links

The MEROPS online database for peptidases and their inhibitors: I04.004
Protein C inhibitor at the US National Library of Medicine Medical Subject Headings (MeSH)

Serpins

inhibitory	Alpha 1-antichymotrypsin Alpha 1-antitrypsin Alpha 2-antiplasmin Antithrombin C1-inhibitor Heparin cofactor II Protein C inhibitor Plasminogen activator inhibitor-1 Plasminogen activator inhibitor-2 Protein Z-related protease inhibitor SERPINA1 SERPINA2 SERPINA3 SERPINA4 SERPINA5 SERPINA6 SERPINA7 SERPINA8 SERPINA9 SERPINA14 SERPINB1 SERPINB2 SERPINB3 SERPINB4 SERPINB5 SERPINB6 SERPINB7 SERPINB8 SERPINB9 SERPINB13 SERPINC1 SERPIND1 SERPINE1 SERPINE2 SERPINE2 SERPINF1 SERPING1 SERPINH1 SERPINI1 SERPINI2

Cross class inhibitory	MENT SCCA-1 CrmA

noninhibitory	Heat shock protein 47 Maspin Ovalbumin SERPINF1 Thyroxine-binding globulin Transcortin SERPINF1

see also disorders of globin and globulin proteins

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Protein C inhibitor

Interactions

See also

Further reading

References

External links