SART3

Squamous cell carcinoma antigen recognized by T cells 3

PDB rendering based on 2do4.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2DO4

Identifiers

Symbols

SART3 ; DSAP1; P100; RP11-13G14; TIP110; p110; p110(nrb)

External IDs

OMIM: 611684 MGI: 1858230 HomoloGene: 40977 GeneCards: SART3 Gene

Gene ontology
Molecular function	• nucleotide binding • protein binding • U6 snRNA binding • U4 snRNA binding • U6atac snRNA binding • histone binding • poly(A) RNA binding • ubiquitin-specific protease binding
Cellular component	• nucleus • nucleoplasm • U6atac snRNP • cytoplasm • Cajal body • nuclear speck • U4/U6 x U5 tri-snRNP complex • U4/U6 snRNP • U4atac/U6atac snRNP
Biological process	• spliceosomal tri-snRNP complex assembly • spliceosomal complex assembly • spliceosomal snRNP assembly • mRNA splicing, via spliceosome • cell morphogenesis • nucleosome assembly • regulation of gene expression • homeostasis of number of cells • hematopoietic stem cell proliferation • positive regulation of histone deubiquitination
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
108.52 – 108.56 Mb

Chr 5:
113.74 – 113.77 Mb

PubMed search

Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene.^[1]^[1]^[2]^[2]^[3]

The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.^[3]

Interactions

SART3 has been shown to interact with RNPS1^[4] and Androgen receptor.^[5]

References

1 2 Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (March 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
1 2 Harada K, Yamada A, Mine T, Kawagoe N, Takasu H, Itoh K (April 2000). "Mouse homologue of the human SART3 gene encoding tumor-rejection antigen". Jpn J Cancer Res 91 (2): 239–47. doi:10.1111/j.1349-7006.2000.tb00937.x. PMID 10761712.
1 2 "Entrez Gene: SART3 squamous cell carcinoma antigen recognized by T cells 3".
↑ Harada, K; Yamada A; Yang D; Itoh K; Shichijo S (September 2001). "Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation". Int. J. Cancer (United States) 93 (5): 623–8. doi:10.1002/ijc.1391. ISSN 0020-7136. PMID 11477570.
↑ Liu, Ying; Kim Byung Oh; Kao Chinghai; Jung Chaeyong; Dalton James T; He Johnny J (May 2004). "Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation". J. Biol. Chem. (United States) 279 (21): 21766–73. doi:10.1074/jbc.M314321200. ISSN 0021-9258. PMID 15031286.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yang D, Nakao M, Shichijo S, et al. (1999). "Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients". Cancer Res. 59 (16): 4056–63. PMID 10463607.
Tanaka S, Tsuda N, Kawano K, et al. (2001). "Expression of tumor-rejection antigens in gynecologic cancers". Jpn. J. Cancer Res. 91 (11): 1177–84. doi:10.1111/j.1349-7006.2000.tb00902.x. PMID 11092984.
Harada K, Yamada A, Yang D, et al. (2001). "Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation". Int. J. Cancer 93 (5): 623–8. doi:10.1002/ijc.1391. PMID 11477570.
Sasatomi T, Suefuji Y, Matsunaga K, et al. (2002). "Expression of tumor rejection antigens in colorectal carcinomas". Cancer 94 (6): 1636–41. doi:10.1002/cncr.10421. PMID 11920522.
Liu Y, Li J, Kim BO, et al. (2002). "HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110". J. Biol. Chem. 277 (26): 23854–63. doi:10.1074/jbc.M200773200. PMID 11959860.
Bell M, Schreiner S, Damianov A, et al. (2002). "p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor". EMBO J. 21 (11): 2724–35. doi:10.1093/emboj/21.11.2724. PMC 126028. PMID 12032085.
Nottrott S, Urlaub H, Lührmann R (2002). "Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins". EMBO J. 21 (20): 5527–38. doi:10.1093/emboj/cdf544. PMC 129076. PMID 12374753.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Stanĕk D, Rader SD, Klingauf M, Neugebauer KM (2003). "Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies". J. Cell Biol. 160 (4): 505–16. doi:10.1083/jcb.200210087. PMC 2173746. PMID 12578909.
Damianov A, Schreiner S, Bindereif A (2004). "Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP". Mol. Cell. Biol. 24 (4): 1700–8. doi:10.1128/MCB.24.4.1700-1708.2004. PMC 344176. PMID 14749385.
Liu Y, Kim BO, Kao C, et al. (2004). "Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation". J. Biol. Chem. 279 (21): 21766–73. doi:10.1074/jbc.M314321200. PMID 15031286.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Medenbach J, Schreiner S, Liu S, et al. (2004). "Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling". Mol. Cell. Biol. 24 (17): 7392–401. doi:10.1128/MCB.24.17.7392-7401.2004. PMC 506986. PMID 15314151.
Stanĕk D, Neugebauer KM (2004). "Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer". J. Cell Biol. 166 (7): 1015–25. doi:10.1083/jcb.200405160. PMC 2172029. PMID 15452143.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

PDB gallery

2do4: Solution structure of the RNA binding domain of squamous cell carcinoma antigen recognized by T cells 3

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SART3

Interactions

References

Further reading