S1PR2
Sphingosine-1-phosphate receptor 2 also known as S1PR2 or S1P2 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).[1]
Function
This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation.[1]
See also
References
Further reading
- Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.". Ann. N. Y. Acad. Sci. 905: 54–60. doi:10.1111/j.1749-6632.2000.tb06537.x. PMID 10818441.
- Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso 47 (4 Suppl): 496–502. PMID 11915348.
- MacLennan AJ, Browe CS, Gaskin AA, et al. (1994). "Cloning and characterization of a putative G-protein coupled receptor potentially involved in development.". Mol. Cell. Neurosci. 5 (3): 201–9. doi:10.1006/mcne.1994.1024. PMID 8087418.
- Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9.". Biochem. Biophys. Res. Commun. 227 (2): 608–14. doi:10.1006/bbrc.1996.1553. PMID 8878560.
- Van Brocklyn JR, Tu Z, Edsall LC, et al. (1999). "Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218.". J. Biol. Chem. 274 (8): 4626–32. doi:10.1074/jbc.274.8.4626. PMID 9988698.
- Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5.". J. Biol. Chem. 274 (27): 18997–9002. doi:10.1074/jbc.274.27.18997. PMID 10383399.
- Windh RT, Lee MJ, Hla T, et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins.". J. Biol. Chem. 274 (39): 27351–8. doi:10.1074/jbc.274.39.27351. PMID 10488065.
- An S, Zheng Y, Bleu T (2000). "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5.". J. Biol. Chem. 275 (1): 288–96. doi:10.1074/jbc.275.1.288. PMID 10617617.
- Himmel HM, Meyer Zu Heringdorf D, Graf E, et al. (2000). "Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes.". Mol. Pharmacol. 58 (2): 449–54. PMID 10908314.
- Hla T (April 2001). "Sphingosine 1-phosphate receptors." 64 (1-4): 135–142. doi:10.1016/s0090-6980(01)00109-5. PMID 11331101.
- Mazurais D, Robert P, Gout B, et al. (2002). "Cell type-specific localization of human cardiac S1P receptors.". J. Histochem. Cytochem. 50 (5): 661–70. doi:10.1177/002215540205000507. PMID 11967277.
- Osada M, Yatomi Y, Ohmori T, et al. (2003). "Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist.". Biochem. Biophys. Res. Commun. 299 (3): 483–7. doi:10.1016/S0006-291X(02)02671-2. PMID 12445827.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Vogler R, Sauer B, Kim DS, et al. (2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.". J. Invest. Dermatol. 120 (4): 693–700. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236.
- Kaneider NC, Lindner J, Feistritzer C, et al. (2005). "The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.". FASEB J. 18 (11): 1309–11. doi:10.1096/fj.03-1050fje. PMID 15208267.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Sanchez T, Thangada S, Wu MT, et al. (2005). "PTEN as an effector in the signaling of antimigratory G protein-coupled receptor.". Proc. Natl. Acad. Sci. U.S.A. 102 (12): 4312–7. doi:10.1073/pnas.0409784102. PMC 555509. PMID 15764699.
- Sanchez T, Skoura A, Wu MT, et al. (2007). "Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN.". Arterioscler. Thromb. Vasc. Biol. 27 (6): 1312–8. doi:10.1161/ATVBAHA.107.143735. PMID 17431187.
External links
- "Lysophospholipid Receptors: S1P2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- Lysophospholipid receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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