Missouri Route 49

Route 49
Route information
Maintained by MoDOT
Length:	120 mi (190 km)
Existed:	1922 – present
Major junctions
South end:	U.S. Route 67 north of Poplar Bluff
North end:	Route 19 in Cherryville
Highway system
Missouri State Highway System Interstate US State Supplemental ← Route 48 US 50 →

Route 49 is a highway in eastern Missouri. Its northern terminus is at Route 19 in Cherryville; is southern terminus is at U.S. Route 67 five miles (8 km) east of Williamsville.

The highway runs through the eastern part of the Ozarks and passes through two sections of the Mark Twain National Forest and near Johnson Shut-ins State Park and Taum Sauk Mountain. Lesterville and Annapolis, as well as Johnson Shut-ins State Park, were evacuated in 2005 following a reservoir failure at the Taum Sauk pumped storage plant.

Route 49 is one of the original 1922 state highways. It only ran between Glover and Piedmont and was later extended. It is likely to be renumbered once Interstate 49 is completed to avoid confusion between the routes.