Ribonuclease Z

TRNase Z
Identifiers
EC number 3.1.26.11
CAS number 98148-84-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

TRNase Z (EC 3.1.26.11, 3 tRNase, tRNA 3 endonuclease, RNase Z, 3' tRNase) is an enzyme.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction

endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule

This enzyme does not use a cofactor.

References

  1. ↑ Schiffer, S., Rösch, S. and Marchfelder, A. (2002). "Assigning a function to a conserved group of proteins: the tRNA 3′-processing enzymes". EMBO J. 21 (11): 2769–2777. doi:10.1093/emboj/21.11.2769. PMC 126033. PMID 12032089.
  2. ↑ Mayer, M., Schiffer, S. and Marchfelder, A. (2000). "tRNA 3′ processing in plants: nuclear and mitochondrial activities differ". Biochemistry 39 (8): 2096–2105. doi:10.1021/bi992253e. PMID 10684660.
  3. ↑ Schiffer, S., Helm, M., Theobald-Dietrich, A., Giege, R. and Marchfelder, A. (2001). "The plant tRNA 3′ processing enzyme has a broad substrate spectrum". Biochemistry 40 (28): 8264–8272. doi:10.1021/bi0101953. PMID 11444972.
  4. ↑ Kunzmann, A., Brennicke, A. and Marchfelder, A. (1998). "5′ end maturation and RNA editing have to precede tRNA 3′ processing in plant mitochondria". Proc. Natl. Acad. Sci. USA 95 (1): 108–113. doi:10.1073/pnas.95.1.108. PMC 18142. PMID 9419337.
  5. ↑ Mörl, M. and Marchfelder, A. (2001). "The final cut. The importance of tRNA 3′-processing". EMBO Rep. 2 (1): 17–20. doi:10.1093/embo-reports/kve006. PMC 1083803. PMID 11252717.
  6. ↑ Minagawa, A., Takaku, H., Takagi, M. and Nashimoto, M. (2004). "A novel endonucleolytic mechanism to generate the CCA 3′ termini of tRNA molecules in Thermotoga maritima". J. Biol. Chem. 279 (15): 15688–15697. doi:10.1074/jbc.M313951200. PMID 14749326.
  7. ↑ Takaku, H., Minagawa, A., Takagi, M. and Nashimoto, M. (2003). "A candidate prostate cancer susceptibility gene encodes tRNA 3′ processing endoribonuclease". Nucleic Acids Res. 31 (9): 2272–2278. doi:10.1093/nar/gkg337. PMC 154223. PMID 12711671.

External links

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