Retinyl acetate

Retinyl acetate

Names
IUPAC name (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl acetate
Other names Retinol acetate; Vitamin A acetate; Vitamin A1 acetate; Acetylretinol; all-trans-Retinol acetate; all-trans-Retinyl acetate; all-trans-Vitamin A acetate;
Identifiers
CAS Number	127-47-9 Y
ChemSpider	553599
Jmol interactive 3D	Image
PubChem	638034
InChI InChI=1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+ Key: QGNJRVVDBSJHIZ-QHLGVNSISA-N InChI=1/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+ Key: QGNJRVVDBSJHIZ-QHLGVNSIBE
SMILES O=C(OC/C=C(/C=C/C=C(/C=C/C1=C(/CCCC1(C)C)C)C)C)C
Properties
Chemical formula	C22H32O2
Molar mass	328.50 g·mol−1
Melting point	57 to 58 °C (135 to 136 °F; 330 to 331 K)[1]
Hazards
R-phrases	R38-R63[1]
S-phrases	S36/37[1]
NFPA 704	1 1 0
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Retinyl acetate (retinol acetate, vitamin A acetate) is a natural form of vitamin A which is the acetate ester of retinol. It has potential antineoplastic and chemopreventive activities.^[2][3]

In the United States, retinyl acetate is classified generally recognized as safe (GRAS) in the amounts used to fortify foods with vitamin A.^[4][5]

Teratogenicity

World Health Organization recommendation on Maternal Supplementation During Pregnancy states that "health benefits are expected for the mother and her developing fetus with little risk of detriment to either, from a daily supplement not exceeding 10,000IU [preformed] vitamin A (3000mcg RE) at any time during pregnancy." Preformed Vitamin A refers to retinyl palmitate and retinyl acetate. ^[6]

References