RBMS1
| RNA binding motif, single stranded interacting protein 1 | |||||||||||||
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PDB rendering based on 1x4e. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | RBMS1 ; C2orf12; HCC-4; MSSP; MSSP-1; MSSP-2; MSSP-3; SCR2; YC1 | ||||||||||||
| External IDs | OMIM: 602310 MGI: 1861774 HomoloGene: 9640 GeneCards: RBMS1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5937 | 56878 | |||||||||||
| Ensembl | ENSG00000153250 | ENSMUSG00000026970 | |||||||||||
| UniProt | P29558 | Q91W59 | |||||||||||
| RefSeq (mRNA) | NM_002897 | NM_001141931 | |||||||||||
| RefSeq (protein) | NP_002888 | NP_001135403 | |||||||||||
| Location (UCSC) |
Chr 2: 160.27 – 160.49 Mb |
Chr 2: 60.75 – 60.96 Mb | |||||||||||
| PubMed search | |||||||||||||
RNA-binding motif, single-stranded-interacting protein 1 is a protein that in humans is encoded by the RBMS1 gene.[1][2][3][4]
Function
This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Multiple transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. Several of these were isolated by virtue of their binding to either strand of an upstream element of c-myc (MSSPs), or by phenotypic complementation of cdc2 and cdc13 mutants of yeast (scr2), or as a potential human repressor of HIV-1 and ILR-2 alpha promoter transcription (YC1). A pseudogene for this locus is found on chromosome 12.[4]
Interactions
RBMS1 has been shown to interact with Polymerase (DNA directed), alpha 1.[5]
References
- ↑ Kanaoka Y, Nojima H (August 1994). "SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins". Nucleic Acids Res. 22 (13): 2687–93. doi:10.1093/nar/22.13.2687. PMC 308228. PMID 8041632.
- ↑ Negishi Y, Nishita Y, Saëgusa Y, Kakizaki I, Galli I, Kihara F, Tamai K, Miyajima N, Iguchi-Ariga SM, Ariga H (April 1994). "Identification and cDNA cloning of single-stranded DNA binding proteins that interact with the region upstream of the human c-myc gene". Oncogene 9 (4): 1133–43. PMID 8134115.
- ↑ Takai T, Nishita Y, Iguchi-Ariga SM, Ariga H (February 1995). "Molecular cloning of MSSP-2, a c-myc gene single-strand binding protein: characterization of binding specificity and DNA replication activity". Nucleic Acids Res. 22 (25): 5576–81. doi:10.1093/nar/22.25.5576. PMC 310119. PMID 7838710. Check date values in:
|year= / |date= mismatch(help) - 1 2 "Entrez Gene: RBMS1 RNA binding motif, single stranded interacting protein 1".
- ↑ Niki T, Galli I, Ariga H, Iguchi-Ariga SM (June 2000). "MSSP, a protein binding to an origin of replication in the c-myc gene, interacts with a catalytic subunit of DNA polymerase alpha and stimulates its polymerase activity". FEBS Lett. 475 (3): 209–12. doi:10.1016/S0014-5793(00)01679-3. PMID 10869558.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Haigermoser C, Fujimoto M, Iguchi-Ariga SM, Ariga H (1996). "Cloning and characterization of the genomic DNA of the human MSSP genes". Nucleic Acids Res. 24 (19): 3846–57. doi:10.1093/nar/24.19.3846. PMC 146151. PMID 8871567.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Niki T, Galli I, Ariga H, Iguchi-Ariga SM (2000). "MSSP, a protein binding to an origin of replication in the c-myc gene, interacts with a catalytic subunit of DNA polymerase alpha and stimulates its polymerase activity". FEBS Lett. 475 (3): 209–12. doi:10.1016/S0014-5793(00)01679-3. PMID 10869558.
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