RBM4

RNA binding motif protein 4

PDB rendering based on 2dgt.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2DNQ

Identifiers

Symbols

RBM4 ; LARK; RBM4A; ZCCHC21; ZCRB3A

External IDs

OMIM: 602571 MGI: 1100865 HomoloGene: 82510 GeneCards: RBM4 Gene

Gene ontology
Molecular function	• nucleotide binding • RNA binding • mRNA binding • mRNA 3'-UTR binding • protein binding • zinc ion binding • miRNA binding • poly(A) RNA binding • pre-mRNA intronic binding • pre-mRNA intronic pyrimidine-rich binding
Cellular component	• nucleus • nucleoplasm • nucleolus • cytoplasm • cytoplasmic stress granule • nuclear speck
Biological process	• regulation of alternative mRNA splicing, via spliceosome • cap-independent translational initiation • IRES-dependent translational initiation • RNA processing • mRNA processing • RNA splicing • negative regulation of translation • cell differentiation • negative regulation of translation in response to stress • negative regulation of translation involved in gene silencing by miRNA • entrainment of circadian clock by photoperiod • negative regulation of translational initiation • response to arsenic-containing substance • regulation of nucleocytoplasmic transport • positive regulation of muscle cell differentiation • stress-activated MAPK cascade • circadian regulation of translation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
66.64 – 66.67 Mb

Chr 19:
4.78 – 4.79 Mb

PubMed search

RNA-binding protein 4 is a protein that in humans is encoded by the RBM4 gene.^[1]^[2]^[3]

References

↑ Jackson FR, Banfi S, Guffanti A, Rossi E (Jul 1997). "A novel zinc finger-containing RNA-binding protein conserved from fruitflies to humans". Genomics 41 (3): 444–52. doi:10.1006/geno.1997.4704. PMID 9169144.
↑ Lin JC, Tarn WY (Nov 2005). "Exon selection in alpha-tropomyosin mRNA is regulated by the antagonistic action of RBM4 and PTB". Mol Cell Biol 25 (22): 10111–21. doi:10.1128/MCB.25.22.10111-10121.2005. PMC 1280272. PMID 16260624.
↑ "Entrez Gene: RBM4 RNA binding motif protein 4".

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Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Kar A, Havlioglu N, Tarn WY, Wu JY (2006). "RBM4 interacts with an intronic element and stimulates tau exon 10 inclusion.". J. Biol. Chem. 281 (34): 24479–88. doi:10.1074/jbc.M603971200. PMC 2072872. PMID 16777844.
Markus MA, Heinrich B, Raitskin O, et al. (2006). "WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo.". Exp. Cell Res. 312 (17): 3379–88. doi:10.1016/j.yexcr.2006.07.008. PMID 16934801.
Lin JC, Hsu M, Tarn WY (2007). "Cell stress modulates the function of splicing regulatory protein RBM4 in translation control.". Proc. Natl. Acad. Sci. U.S.A. 104 (7): 2235–40. doi:10.1073/pnas.0611015104. PMC 1893002. PMID 17284590.

PDB gallery

2dgt: Solution structure of the second RNA binding domain in RNA-binding protein 30

2dnq: Solution structure of RNA binding domain 1 in RNA-binding protein 30

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RBM4

References

Further reading