Retinoic acid receptor gamma
Retinoic acid receptor gamma (RAR-γ), also known as NR1B3 (nuclear receptor subfamily 1, group B, member 3) is a nuclear receptor encoded by the RARG gene.[1][2]
Interactions
Retinoic acid receptor gamma has been shown to interact with NCOR1.[3]
See also
References
Further reading
- Leid M, Kastner P, Lyons R, Nakshatri H, Saunders M, Zacharewski T, Chen JY, Staub A, Garnier JM, Mader S (Jan 1992). "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently". Cell 68 (2): 377–95. doi:10.1016/0092-8674(92)90478-U. PMID 1310259.
- Vollberg TM, Nervi C, George MD, Fujimoto W, Krust A, Jetten AM (May 1992). "Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation". Molecular Endocrinology 6 (5): 667–76. doi:10.1210/me.6.5.667. PMID 1318502.
- Lehmann JM, Zhang XK, Pfahl M (Jul 1992). "RAR gamma 2 expression is regulated through a retinoic acid response element embedded in Sp1 sites". Molecular and Cellular Biology 12 (7): 2976–85. doi:10.1128/mcb.12.7.2976. PMC 364511. PMID 1320193.
- Mattei MG, Rivière M, Krust A, Ingvarsson S, Vennström B, Islam MQ, Levan G, Kautner P, Zelent A, Chambon P (Aug 1991). "Chromosomal assignment of retinoic acid receptor (RAR) genes in the human, mouse, and rat genomes". Genomics 10 (4): 1061–9. doi:10.1016/0888-7543(91)90199-O. PMID 1655630.
- Kastner P, Krust A, Mendelsohn C, Garnier JM, Zelent A, Leroy P, Staub A, Chambon P (Apr 1990). "Murine isoforms of retinoic acid receptor gamma with specific patterns of expression". Proceedings of the National Academy of Sciences of the United States of America 87 (7): 2700–4. doi:10.1073/pnas.87.7.2700. PMC 53758. PMID 2157210.
- Giguère V, Shago M, Zirngibl R, Tate P, Rossant J, Varmuza S (May 1990). "Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo". Molecular and Cellular Biology 10 (5): 2335–40. doi:10.1128/mcb.10.5.2335. PMC 360581. PMID 2157970.
- Ishikawa T, Umesono K, Mangelsdorf DJ, Aburatani H, Stanger BZ, Shibasaki Y, Imawari M, Evans RM, Takaku F (Jun 1990). "A functional retinoic acid receptor encoded by the gene on human chromosome 12". Molecular Endocrinology 4 (6): 837–44. doi:10.1210/mend-4-6-837. PMID 2172793.
- Krust A, Kastner P, Petkovich M, Zelent A, Chambon P (Jul 1989). "A third human retinoic acid receptor, hRAR-gamma". Proceedings of the National Academy of Sciences of the United States of America 86 (14): 5310–4. doi:10.1073/pnas.86.14.5310. PMC 297611. PMID 2546152.
- Renaud JP, Rochel N, Ruff M, Vivat V, Chambon P, Gronemeyer H, Moras D (Dec 1995). "Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid". Nature 378 (6558): 681–9. doi:10.1038/378681a0. PMID 7501014.
- Zhou L, Pang J, Munroe DG, Lau C (May 1993). "A human retinoic acid receptor gamma isoform is homologous to the murine retinoic acid receptor gamma 7". Nucleic Acids Research 21 (10): 2520. doi:10.1093/nar/21.10.2520. PMC 309563. PMID 7685085.
- Zitnik RJ, Kotloff RM, Latifpour J, Zheng T, Whiting NL, Schwalb J, Elias JA (Feb 1994). "Retinoic acid inhibition of IL-1-induced IL-6 production by human lung fibroblasts". Journal of Immunology 152 (3): 1419–27. PMID 8301142.
- Botling J, Castro DS, Oberg F, Nilsson K, Perlmann T (Apr 1997). "Retinoic acid receptor/retinoid X receptor heterodimers can be activated through both subunits providing a basis for synergistic transactivation and cellular differentiation". The Journal of Biological Chemistry 272 (14): 9443–9. doi:10.1074/jbc.272.14.9443. PMID 9083083.
- Lømo J, Smeland EB, Ulven S, Natarajan V, Blomhoff R, Gandhi U, Dawson MI, Blomhoff HK (Apr 1998). "RAR-, not RXR, ligands inhibit cell activation and prevent apoptosis in B-lymphocytes". Journal of Cellular Physiology 175 (1): 68–77. doi:10.1002/(SICI)1097-4652(199804)175:1<68::AID-JCP8>3.0.CO;2-A. PMID 9491782.
- Klaholz BP, Renaud JP, Mitschler A, Zusi C, Chambon P, Gronemeyer H, Moras D (Mar 1998). "Conformational adaptation of agonists to the human nuclear receptor RAR gamma". Nature Structural Biology 5 (3): 199–202. doi:10.1038/nsb0398-199. PMID 9501913.
- Zhang ZP, Gambone CJ, Gabriel JL, Wolfgang CL, Soprano KJ, Soprano DR (Dec 1998). "Arg278, but not Lys229 or Lys236, plays an important role in the binding of retinoic acid by retinoic acid receptor gamma". The Journal of Biological Chemistry 273 (51): 34016–21. doi:10.1074/jbc.273.51.34016. PMID 9852056.
- Yang C, Zhou D, Chen S (Dec 1998). "Modulation of aromatase expression in the breast tissue by ERR alpha-1 orphan receptor". Cancer Research 58 (24): 5695–700. PMID 9865725.
- Nagpal S, Ghosn C, DiSepio D, Molina Y, Sutter M, Klein ES, Chandraratna RA (Aug 1999). "Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor". The Journal of Biological Chemistry 274 (32): 22563–8. doi:10.1074/jbc.274.32.22563. PMID 10428834.
- Egea PF, Mitschler A, Rochel N, Ruff M, Chambon P, Moras D (Jun 2000). "Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid". The EMBO Journal 19 (11): 2592–601. doi:10.1093/emboj/19.11.2592. PMC 212755. PMID 10835357.
- Boudjelal M, Voorhees JJ, Fisher GJ (Mar 2002). "Retinoid signaling is attenuated by proteasome-mediated degradation of retinoid receptors in human keratinocyte HaCaT cells". Experimental Cell Research 274 (1): 130–7. doi:10.1006/excr.2001.5450. PMID 11855864.
PDB gallery |
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| | 1dsz: STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1 |
| 1exa: ENANTIOMER DISCRIMINATION ILLUSTRATED BY CRYSTAL STRUCTURES OF THE HUMAN RETINOIC ACID RECEPTOR HRARGAMMA LIGAND BINDING DOMAIN: THE COMPLEX WITH THE ACTIVE R-ENANTIOMER BMS270394. |
| 1exx: ENANTIOMER DISCRIMINATION ILLUSTRATED BY CRYSTAL STRUCTURES OF THE HUMAN RETINOIC ACID RECEPTOR HRARGAMMA LIGAND BINDING DOMAIN: THE COMPLEX WITH THE INACTIVE S-ENANTIOMER BMS270395. |
| 1fcx: ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARGAMMA-SELECTIVE RETINOID BMS184394 |
| 1fcy: ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARBETA/GAMMA-SELECTIVE RETINOID CD564 |
| 1fcz: ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE PANAGONIST RETINOID BMS181156 |
| 1fd0: ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARGAMMA-SELECTIVE RETINOID SR11254 |
| 1hra: THE SOLUTION STRUCTURE OF THE HUMAN RETINOIC ACID RECEPTOR-BETA DNA-BINDING DOMAIN |
| 2lbd: LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO ALL-TRANS RETINOIC ACID |
| 3lbd: LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO 9-CIS RETINOIC ACID |
| 4lbd: LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO THE SYNTHETIC AGONIST BMS961 |
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| (2.1) Nuclear receptor (Cys4) | subfamily 1 | |
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| subfamily 0 | |
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| (2.4) Cys6 | |
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| CAR | |
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| FXR | |
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| Antagonists |
- FH-535
- GW-9662
- SR-202
- T-0070907
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| Unknown | |
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| Unselective | |
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| PXR | |
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| RAR | Agonists | |
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| Antagonists |
- BMS-195614
- BMS-493
- CD-2665
- ER-50891
- LE-135
- MM-11253
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| RXR | Agonists | |
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| Antagonists |
- HX-531
- HX-630
- LG-100754
- PA-452
- UVI-3003
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| SHR | | See here instead. |
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| TR | |
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