RAP2A

RAP2A, member of RAS oncogene family

PDB rendering based on 1kao.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols RAP2A ; K-REV; KREV; RAP2; RbBP-30
External IDs OMIM: 179540 MGI: 97855 HomoloGene: 10875 GeneCards: RAP2A Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5911 76108
Ensembl ENSG00000125249 ENSMUSG00000051615
UniProt P10114 Q80ZJ1
RefSeq (mRNA) NM_021033 NM_029519
RefSeq (protein) NP_066361 NP_083795
Location (UCSC) Chr 13:
97.43 – 97.47 Mb		 Chr 14:
120.48 – 120.51 Mb
PubMed search

Ras-related protein Rap-2a is a protein that in humans is encoded by the RAP2A gene.[1] RAP2A is a member of the Ras-related protein family.

Interactions

RAP2A has been shown to interact with RUNDC3A,[2] RASSF5[3] and RALGDS.[4]

References

  1. ↑ "Entrez Gene: RAP2A RAP2A, member of RAS oncogene family".
  2. ↑ Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J (Mar 1998). "Identification of a specific effector of the small GTP-binding protein Rap2". European Journal of Biochemistry / FEBS 252 (2): 290–8. doi:10.1046/j.1432-1327.1998.2520290.x. PMID 9523700.
  3. ↑ Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.
  4. ↑ Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Mar 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". The Journal of Biological Chemistry 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114.

Further reading

  • Lerosey I, Chardin P, de Gunzburg J, Tavitian A (Mar 1991). "The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis". The Journal of Biological Chemistry 266 (7): 4315–21. PMID 1900290. 
  • Pizon V, Chardin P, Lerosey I, Olofsson B, Tavitian A (Aug 1988). "Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region". Oncogene 3 (2): 201–4. PMID 3045729. 
  • Farrell FX, Yamamoto K, Lapetina EG (Jan 1993). "Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated". The Biochemical Journal. 289 ( Pt 2) (Pt 2): 349–55. PMC 1132174. PMID 8424780. 
  • Cherfils J, Ménétrey J, Le Bras G, Janoueix-Lerosey I, de Gunzburg J, Garel JR, Auzat I (Sep 1997). "Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS". The EMBO Journal 16 (18): 5582–91. doi:10.1093/emboj/16.18.5582. PMC 1170190. PMID 9312017. 
  • Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J (Mar 1998). "Identification of a specific effector of the small GTP-binding protein Rap2". European Journal of Biochemistry / FEBS 252 (2): 290–8. doi:10.1046/j.1432-1327.1998.2520290.x. PMID 9523700. 
  • Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Mar 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". The Journal of Biological Chemistry 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114. 
  • Linnemann T, Geyer M, Jaitner BK, Block C, Kalbitzer HR, Wittinghofer A, Herrmann C (May 1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily". The Journal of Biological Chemistry 274 (19): 13556–62. doi:10.1074/jbc.274.19.13556. PMID 10224125. 
  • Ménétrey J, Cherfils J (Nov 1999). "Structure of the small G protein Rap2 in a non-catalytic complex with GTP". Proteins 37 (3): 465–73. doi:10.1002/(SICI)1097-0134(19991115)37:3<465::AID-PROT13>3.0.CO;2-O. PMID 10591105. 
  • de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL (Jul 2000). "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs". The Journal of Biological Chemistry 275 (27): 20829–36. doi:10.1074/jbc.M001113200. PMID 10777494. 
  • Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (Jul 2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nature Neuroscience 3 (7): 661–9. doi:10.1038/76615. PMID 10862698. 
  • Traver S, Bidot C, Spassky N, Baltauss T, De Tand MF, Thomas JL, Zalc B, Janoueix-Lerosey I, Gunzburg JD (Aug 2000). "RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao". The Biochemical Journal. 350 Pt 1 (Pt 1): 19–29. doi:10.1042/0264-6021:3500019. PMC 1221220. PMID 10926822. 
  • Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T (Nov 2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras". The Journal of Biological Chemistry 276 (45): 42219–25. doi:10.1074/jbc.M105760200. PMID 11524421. 
  • Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081. 
  • Song C, Satoh T, Edamatsu H, Wu D, Tadano M, Gao X, Kataoka T (Nov 2002). "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon". Oncogene 21 (53): 8105–13. doi:10.1038/sj.onc.1206003. PMID 12444546. 
  • Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ (Feb 2003). "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2". Biochimica Et Biophysica Acta 1593 (2-3): 141–9. doi:10.1016/S0167-4889(02)00365-8. PMID 12581858. 
  • Machida N, Umikawa M, Takei K, Sakima N, Myagmar BE, Taira K, Uezato H, Ogawa Y, Kariya K (Apr 2004). "Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase". The Journal of Biological Chemistry 279 (16): 15711–4. doi:10.1074/jbc.C300542200. PMID 14966141. 
  • Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". The Journal of Biological Chemistry 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288. 
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