Precursor B-cell lymphoblastic leukemia

Precursor B-cell lymphoblastic leukemia
A Wright's stained bone marrow aspirate smear from a person with precursor B-cell acute lymphoblastic leukemia.
Classification and external resources
Specialty	oncology
ICD-10	C83.5
ICD-O	M 9836/3
MeSH	D015452

Precursor B-cell lymphoblastic leukemia is a form of lymphoid leukemia in which too many B-cell lymphoblasts (immature white blood cells) are found in the blood and bone marrow. It is the most common type of acute lymphoblastic leukemia (ALL). It is sometimes additionally classified as a lymphoma, as designated leukemia/lymphoma.

It consists of the following subtypes:^[1]

t(9;22)-BCR/ ABL
t(v;11q23)-MLL rearrangement
t(1;19)-E2A/PBX1
t(12;21)-ETV/ CBFα
t(17;19)-E2A-HLF

Molecular Mechanisms

One interesting model of precursor B ALL shows aberrant function of a single gene, namely Pax5, as capable to change phenotype of B cells toward precursor cells.^[2]^[3]

References

↑ Randolph TR (2004). "Advances in acute lymphoblastic leukemia". Clin Lab Sci 17 (4): 235–45. PMID 15559730.
↑ Carotta S, Nutt SL (March 2008). "Losing B cell identity". BioEssays 30 (3): 203–7. doi:10.1002/bies.20725. PMID 18293359.
↑ Den Boer ML, van Slegtenhorst M, De Menezes RX, et al. (February 2009). "A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study". Lancet Oncol. 10 (2): 125–34. doi:10.1016/S1470-2045(08)70339-5. PMC 2707020. PMID 19138562.

This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".

External links

Precursor B-lymphoblastic leukemia entry in the public domain NCI Dictionary of Cancer Terms

Hematological malignancy/leukemia histology (ICD-O 9590–9989, C81–C96, 200–208)
Lymphoid/Lymphoproliferative, Lymphomas/Lymphoid leukemias (9590–9739, 9800–9839)

B cell
(lymphoma,
leukemia)
(most CD19

CD20)

By
development/
marker

TdT+	ALL (Precursor B acute lymphoblastic leukemia/lymphoma)

CD5+	naive B cell (CLL/SLL) mantle zone (Mantle cell)

CD22+	Prolymphocytic CD11c+ (Hairy cell leukemia)

CD79a+	germinal center/follicular B cell (Follicular Burkitt's GCB DLBCL Primary cutaneous follicle center lymphoma) marginal zone/marginal zone B-cell (Splenic marginal zone MALT Nodal marginal zone Primary cutaneous marginal zone lymphoma)

RS (CD15+, CD30+)	Classic Hodgkin's lymphoma (Nodular sclerosis) CD20+ (Nodular lymphocyte predominant Hodgkin's lymphoma)

PCDs/PP (CD38+/CD138+)	see immunoproliferative immunoglobulin disorders

By infection

KSHV (Primary effusion)
EBV (Lymphomatoid granulomatosis
Post-transplant lymphoproliferative disorder)
HIV (AIDS-related lymphoma)
Helicobacter pylori (MALT lymphoma)

Cutaneous

T/NK

T cell
(lymphoma,
leukemia)
(most CD3

CD4
CD8)

By
development/
marker

TdT+: ALL (Precursor T acute lymphoblastic leukemia/lymphoma)

prolymphocyte (Prolymphocytic)

Cutaneous

MF+variants	indolent: Mycosis fungoides Pagetoid reticulosis Granulomatous slack skin aggressive: Sézary disease Adult T-cell leukemia/lymphoma

Non-MF	CD30-: Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma Pleomorphic T-cell lymphoma Lymphomatoid papulosis type B CD30+: CD30+ cutaneous T-cell lymphoma Secondary cutaneous CD30+ large-cell lymphoma Lymphomatoid papulosis type A

Other
peripheral

By infection

HTLV-1 (Adult T-cell leukemia/lymphoma)

NK cell/
(most CD56)

T or NK

Lymphoid+
myeloid

Acute biphenotypic leukaemia

Lymphocytosis

Cutaneous lymphoid hyperplasia

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