Prazepine

Not to be confused with Prazepam.

Not to be confused with Imipramine.

Prazepine
Names

IUPAC name 3-(6,11-dihydrobenzo[c] [1]benzazepin-5-yl)-N,N-dimethylpropan-1-amine
Other names Propazepine, Proazepine
Identifiers
CAS Number	73-07-4
ChemSpider	264414
Jmol interactive 3D	Image
PubChem	299322
SMILES CN(C)CCCN1CC2=CC=CC=C2CC3=CC=CC=C31
Properties
Chemical formula	C₁₉H₂₄N₂
Molar mass	280.42 g·mol⁻¹
Density	1.041 g/cm3^[1]
Boiling point	419.8° C^[1]
Hazards
Flash point	188.7° C^[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Prazepine is a tricyclic antidepressant (TCA).^[2] It is confused with Imipramine^[2]^[3] It can be synthesized chemically ^[4]^[5]

References

1 2 3 "Prazepine 73-07-4". chemnet.com.
1 2 Benešová, O.; Bohdanecký, Z.; Votava, Z. (1962). "Electrophysiological comparison of the action of imipramine and propazepine". Psychopharmacologia 3 (6): 423–431. doi:10.1007/BF00411159. PMID 13967414.
↑ This page redirected from 4 April 2011‎ to 22 October 2015
↑ Werner, L. H.; Ricca, S.; Mohacsi, E.; Rossi, A.; Arya, V. P. (1965). "Derivatives of Morphanthridine". Journal of Medicinal Chemistry 8: 74–80. doi:10.1021/jm00325a016. PMID 14287270.
↑ Jílek, J. O.; Pomykáček, J.; Svátek, E.; Seidlová, V.; Rajšner, M.; Pelz, K.; Hoch, B.; Protiva, M. (1965). "Neurotrope und psychotrope substanzen II. Morphanthridin und derivate. Neue synthese des propazepins" [Neurotropic and psychotropic substances II. Morphanthridin and derivatives. New Synthesis of propazepins]. Collection of Czechoslovak Chemical Communications 30 (2): 445–462. doi:10.1135/cccc19650445.

Antidepressants (N06A)

Specific reuptake inhibitors and/or receptor modulators

SSRIs	Citalopram Escitalopram Fluoxetine^# Fluvoxamine Indalpine^‡ Paroxetine Sertraline Zimelidine^‡

SNRIs	Desvenlafaxine Duloxetine Levomilnacipran Milnacipran Tofenacin Venlafaxine

NRIs	Atomoxetine Reboxetine Viloxazine

NDRIs	Amineptine^‡ Nomifensine^‡

SARIs	Etoperidone Nefazodone^‡ Trazodone

SMSs	Vilazodone Vortioxetine

Others	Agomelatine Amisulpride Amitriptyline/perphenazine Buprenorphine Bupropion Etryptamine^‡ Flupentixol/melitracen Esketamine Ketamine Indeloxazine Lurasidone Medifoxamine^‡ Metryptamine^‡ Olanzapine/fluoxetine Oxaflozane^‡ Quetiapine Tandospirone Teniloxazine Tianeptine Tranylcypromine/trifluoperazine

Tricyclic and tetracyclic antidepressants

TCAs	Amineptine^‡ Amitriptyline^# Amitriptylinoxide Butriptyline^‡ Clomipramine^# Demexiptiline^‡ Desipramine Dibenzepin Dimetacrine^‡ Dosulepin Doxepin Imipramine Imipraminoxide^‡ Iprindole^‡ Lofepramine Melitracen Metapramine^‡ Nitroxazepine Nortriptyline Noxiptiline Opipramol Pipofezine Propizepine^‡ Protriptyline Quinupramine^‡ Tianeptine Trimipramine

TeCAs	Amoxapine Maprotiline Mianserin Mirtazapine Setiptiline

Others	Tiazesim

Monoamine oxidase inhibitors

Non-selective	Irreversible: Benmoxin^‡ Iproclozide^‡ Iproniazid^‡ Isocarboxazid Mebanazine^‡ Nialamide^‡ Octamoxin^‡ Phenelzine Pheniprazine^‡ Phenoxypropazine^‡ Pivhydrazine^‡ Safrazine^‡ Tranylcypromine Reversible: Caroxazone^‡

MAO_A-selective	Reversible: Bifemelane Eprobemide Metralindole Minaprine^‡ Moclobemide Pirlindole Tetrindole Toloxatone

MAO_B-Selective	Irreversible: Selegiline

Adjunctive therapies

Atypical antipsychotics (aripiprazole, lurasidone, olanzapine, quetiapine) Buspirone Lithium (lithium carbonate, lithium citrate) Thyroid hormones (triiodothyronine (T₃), levothyroxine (T₄))

Miscellaneous

Ademetionine (SAMe) Hypericum perforatum (St. John's Wort) Oxitriptan (5-HTP) Tryptophan

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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