Phosphoacetylglucosamine mutase

In enzymology, a phosphoacetylglucosamine mutase (EC 5.4.2.3) is an enzyme that catalyzes the chemical reaction

N-acetyl-alpha-D-glucosamine 1-phosphate N-acetyl-D-glucosamine 6-phosphate

Hence, this enzyme has one substrate, N-acetyl-alpha-D-glucosamine 1-phosphate, and one product, N-acetyl-D-glucosamine 6-phosphate.

This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is N-acetyl-alpha-D-glucosamine 1,6-phosphomutase. Other names in common use include acetylglucosamine phosphomutase, acetylglucosamine phosphomutase, acetylaminodeoxyglucose phosphomutase, phospho-N-acetylglucosamine mutase, and N-acetyl-D-glucosamine 1,6-phosphomutase. This enzyme participates in aminosugars metabolism. This enzyme has at least one effector, N-Acetyl-D-glucosamine 1,6-bisphosphate.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1WJW, 2DKA, 2DKC, and 2DKD.

References

• Carlson DM (1966). "Phosphoacetylglucosamine mutase from pig submaxillary gland; Chapter 24. Phosphoacetylglucosamine mutase from pig submaxillary gland". Methods Enzymol. Methods in Enzymology 8: 179–182. doi:10.1016/0076-6879(66)08028-5. ISBN 978-0-12-181808-1. 
• LELOIR LF, CARDINI CE (1956). "Enzymes acting on glucosamine phosphate". Biochim. Biophys. Acta 20 (1): 33–42. doi:10.1016/0006-3002(56)90259-1. PMID 13315346. 
• Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 6, 1972, p. 407-477.
• Reissig JL and Leloir LF (1966). "Phosphoacetylglucosamine mutase from Neurospora; Chapter 23. Phosphoacetylglucosamine mutase from Neurospora". Methods Enzymol. Methods in Enzymology 8: 175–178. doi:10.1016/0076-6879(66)08027-3. ISBN 978-0-12-181808-1.