Glycosylceramidase
In enzymology, a glycosylceramidase (EC 3.2.1.62) is an enzyme that catalyzes the chemical reaction
- glycosyl-N-acylsphingosine + H2O
N-acylsphingosine + a sugar
Thus, the two substrates of this enzyme are glycosyl-N-acylsphingosine and H2O, whereas its two products are N-acylsphingosine and sugar.
This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is glycosyl-N-acylsphingosine glycohydrolase. Other names in common use include phlorizin hydrolase, phloretin-glucosidase, glycosyl ceramide glycosylhydrolase, cerebrosidase, phloridzin beta-glucosidase, lactase-phlorizin hydrolase, and phloridzin glucosidase.
References
- Leese HJ, Semenza G (1973). "On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase". J. Biol. Chem. 248 (23): 8170–3. PMID 4752949.
- Lorenz-Meyer H, Blum AL, Haemmerli HP, Semenza G (1972). "A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase". Eur. J. Clin. Invest. 2 (5): 326–31. doi:10.1111/j.1365-2362.1972.tb00658.x. PMID 5082068.
- Malathi P, Crane RK (1969). "Phlorizin hydrolase: a beta-glucosidase of hamster intestinal brush border membrane". Biochim. Biophys. Acta 173 (2): 245–56. doi:10.1016/0005-2736(69)90108-4. PMID 5774775.
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