PVSRIPO

PVSRIPO, or PVS-RIPO, is the name of a modified polio virus that has recently shown promise for treating cancer. It is the focus of clinical trials being conducted at Duke University.[1]

A 2014 review article in the peer-reviewed journal Cancer by some of the main researchers on PVSRIPO concluded that

The recent promise of oncolytic virotherapy in the clinic, [that is], our observations with PVSRIPO, demonstrate that relentless preclinical, mechanistic research addressing all aspects of the virus:host relationship can yield promising clinical results in the most difficult oncologic indications that resist all available conventional therapy.[1]:3284

A website at Duke University describes many of properties of PVSRIPO, and historical background about using viruses to oppose cancer.[2] According to that website,

The FDA approved clinical trials with PVS-RIPO in brain tumor patients recently. Since May 2012, five brain tumor patients have been treated. Remarkably, there have been no toxic side effects with PVS-RIPO whatsoever, even at the highest possible dose (10 billion infectious virus particles).

The potential value of PVSRIPO was the focus of a 2015 story on Newsmax,[3] and a 2015 story on 60 Minutes.[4]

See also

References

  1. 1 2 Brown, Michael C.; Dobrikova, Elena Y.; Dobrikov, Mikhail I.; Walton, Ross W.; Gemberling, Sarah L.; Nair, Smita K.; ...; Gromeier, Matthias (1 November 2014). "Oncolytic polio virotherapy of cancer". Cancer 120 (21): 3277–3286. doi:10.1002/cncr.28862. PMID 24939611.
  2. ↑ "Targeting Cancer with Genetically Engineered Poliovirus (PVS-RIPO)". The Preston Robert Tisch Brain Tumor Center.
  3. ↑ Tate, Nick (30 March 2015). "Can the Polio Virus Cure Cancer?". Newsmax. Retrieved 31 March 2015.
  4. ↑ "Using polio to kill cancer: A producers' notebook". 60 Minutes Overtime. CBS News. 29 March 2015. Retrieved 31 March 2015.
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