PSMF1

Proteasome inhibitor subunit 1

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2VT8, 4OUH

Identifiers

Symbols

PSMF1 ; PI31

External IDs

MGI: 1346072 HomoloGene: 38231 GeneCards: PSMF1 Gene

Gene ontology
Molecular function	• endopeptidase inhibitor activity • protein binding • proteasome binding
Cellular component	• nucleoplasm • cytoplasm • endoplasmic reticulum • cytosol • proteasome core complex • membrane
Biological process	• G1/S transition of mitotic cell cycle • protein polyubiquitination • mitotic cell cycle • stimulatory C-type lectin receptor signaling pathway • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • ubiquitin-dependent protein catabolic process • regulation of cellular amino acid metabolic process • apoptotic process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • gene expression • negative regulation of endopeptidase activity • programmed cell death • viral process • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • cellular nitrogen compound metabolic process • antigen processing and presentation of exogenous peptide antigen via MHC class I • regulation of apoptotic process • negative regulation of apoptotic process • small molecule metabolic process • innate immune response • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • negative regulation of canonical Wnt signaling pathway • positive regulation of canonical Wnt signaling pathway • negative regulation of proteasomal protein catabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 20:
1.11 – 1.19 Mb

Chr 2:
151.72 – 151.74 Mb

PubMed search

Proteasome inhibitor PI31 subunit is a protein that in humans is encoded by the PSMF1 gene.^[1]^[2]

Function

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene.^[2]

References

↑ Tanahashi N, Kawahara H, Murakami Y, Tanaka K (Apr 1999). "The proteasome-dependent proteolytic system". Molecular Biology Reports 26 (1–2): 3–9. doi:10.1023/A:1006909522731. PMID 10363639.
1 2 "Entrez Gene: PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)".

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Zaiss DM, Standera S, Kloetzel PM, Sijts AJ (Oct 2002). "PI31 is a modulator of proteasome formation and antigen processing". Proceedings of the National Academy of Sciences of the United States of America 99 (22): 14344–9. Bibcode:2002PNAS...9914344Z. doi:10.1073/pnas.212257299. PMC 137886. PMID 12374861.
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Proteasome endopeptidase complex subunits (EC 3.4.25.1)

A (alpha subunits)	PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8

B (beta subunits)	PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMB10

C (ATPases)	PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6

D (non-ATPases)	PSMD1 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14

E (activator subunits)	PSME1 PSME2 PSME3 PSME4

F (inhibitor subunit)	PSMF1

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PSMF1

Function

References

Further reading