PSME4

Proteasome activator subunit 4

Identifiers

PSME4 ; PA200

External IDs

OMIM: 607705 MGI: 2143994 HomoloGene: 113742 GeneCards: PSME4 Gene

Gene ontology
Molecular function	• protein binding • peptidase activator activity • lysine-acetylated histone binding
Cellular component	• nucleus • cytosol • nuclear speck • spermatoproteasome complex
Biological process	• protein polyubiquitination • mitotic cell cycle • stimulatory C-type lectin receptor signaling pathway • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • DNA repair • regulation of cellular amino acid metabolic process • apoptotic process • cellular response to DNA damage stimulus • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • multicellular organismal development • gene expression • proteasomal ubiquitin-independent protein catabolic process • positive regulation of peptidase activity • programmed cell death • viral process • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • cellular nitrogen compound metabolic process • spermatogenesis, exchange of chromosomal proteins • antigen processing and presentation of exogenous peptide antigen via MHC class I • regulation of apoptotic process • negative regulation of apoptotic process • small molecule metabolic process • innate immune response • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • negative regulation of canonical Wnt signaling pathway • positive regulation of canonical Wnt signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
53.86 – 53.97 Mb

Chr 11:
30.77 – 30.88 Mb

PubMed search

Proteasome activator complex subunit 4 is a protein that in humans is encoded by the PSME4 gene.^[1]^[2]^[3]

References

↑ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
↑ Ustrell V, Hoffman L, Pratt G, Rechsteiner M (Jul 2002). "PA200, a nuclear proteasome activator involved in DNA repair". The EMBO Journal 21 (13): 3516–25. doi:10.1093/emboj/cdf333. PMC 126083. PMID 12093752.
↑ "Entrez Gene: PSME4 proteasome (prosome, macropain) activator subunit 4".

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Proteasome endopeptidase complex subunits (EC 3.4.25.1)

A (alpha subunits)	PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMA8

B (beta subunits)	PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PSMB10

C (ATPases)	PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6

D (non-ATPases)	PSMD1 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14

E (activator subunits)	PSME1 PSME2 PSME3 PSME4

F (inhibitor subunit)	PSMF1

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PSME4

References

Further reading