PPP6C
| Protein phosphatase 6, catalytic subunit | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | PPP6C ; PP6; PP6C | ||||||||||||
| External IDs | OMIM: 612725 MGI: 1915107 HomoloGene: 68273 GeneCards: PPP6C Gene | ||||||||||||
| EC number | 3.1.3.16 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5537 | 67857 | |||||||||||
| Ensembl | ENSG00000119414 | ENSMUSG00000026753 | |||||||||||
| UniProt | O00743 | Q9CQR6 | |||||||||||
| RefSeq (mRNA) | NM_001123355 | NM_024209 | |||||||||||
| RefSeq (protein) | NP_001116827 | NP_077171 | |||||||||||
| Location (UCSC) |
Chr 9: 125.15 – 125.19 Mb |
Chr 2: 39.19 – 39.23 Mb | |||||||||||
| PubMed search | |||||||||||||
Serine/threonine-protein phosphatase 6 catalytic subunit is an enzyme that in humans is encoded by the PPP6C gene.[1][2]
Interactions
PPP6C has been shown to interact with IGBP1.[3][4]
References
- ↑ Bastians H, Krebber H, Vetrie D, Hoheisel J, Lichter P, Ponstingl H, Joos S (Jul 1997). "Localization of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3". Genomics 41 (2): 296–7. doi:10.1006/geno.1997.4640. PMID 9143513.
- ↑ "Entrez Gene: PPP6C protein phosphatase 6, catalytic subunit".
- ↑ Gingras, Anne-Claude; Caballero Michael; Zarske Marcel; Sanchez Amy; Hazbun Tony R; Fields Stanley; Sonenberg Nahum; Hafen Ernst; Raught Brian; Aebersold Ruedi (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Mol. Cell Proteomics (United States) 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. ISSN 1535-9476. PMID 16085932.
- ↑ Chen, J; Peterson R T; Schreiber S L (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochem. Biophys. Res. Commun. (UNITED STATES) 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. ISSN 0006-291X. PMID 9647778.
Further reading
- Bastians H, Ponstingl H (1997). "The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation.". J. Cell. Sci. 109 (Pt 12): 2865–74. PMID 9013334.
- Chen J, Peterson RT, Schreiber SL (1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6.". Biochem. Biophys. Res. Commun. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
- Nasu-Nishimura Y, Hayashi T, Ohishi T, et al. (2006). "Role of the Rho GTPase-activating protein RICS in neurite outgrowth.". Genes Cells 11 (6): 607–14. doi:10.1111/j.1365-2443.2006.00966.x. PMID 16716191.
- Stefansson B, Brautigan DL (2006). "Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon.". J. Biol. Chem. 281 (32): 22624–34. doi:10.1074/jbc.M601772200. PMID 16769727.
- Stefansson B, Brautigan DL (2007). "Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells.". Cell Cycle 6 (11): 1386–92. doi:10.4161/cc.6.11.4276. PMID 17568194.
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