PPP3R2
| Protein phosphatase 3, regulatory subunit B, beta | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbols | PPP3R2 ; PPP3RL | ||||||||
| External IDs | OMIM: 613821 MGI: 107171 HomoloGene: 133815 ChEMBL: 4275 GeneCards: PPP3R2 Gene | ||||||||
| EC number | 3.1.3.16 | ||||||||
| |||||||||
| Orthologs | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | 5535 | 19059 | |||||||
| Ensembl | ENSG00000188386 | ENSMUSG00000028310 | |||||||
| UniProt | Q96LZ3 | Q63811 | |||||||
| RefSeq (mRNA) | NM_147180 | NM_001004025 | |||||||
| RefSeq (protein) | NP_671709 | NP_001004025 | |||||||
| Location (UCSC) |
Chr 9: 101.59 – 101.6 Mb |
Chr 4: 49.68 – 49.68 Mb | |||||||
| PubMed search | |||||||||
Calcineurin subunit B type 2 is a protein that in humans is encoded by the PPP3R2 gene.[1][2] Among its related pathways are MAPK signaling pathway[3] and GPCR pathway.[4] GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CHP1.[5]
References
- ↑ Liu L, Zhang J, Yuan J, Dang Y, Yang C, Chen X, Xu J, Yu L (May 2005). "Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis". Mol Biol Rep 32 (1): 41–5. doi:10.1007/s11033-004-4250-4. PMID 15865209.
- ↑ "Entrez Gene: PPP3R2 protein phosphatase 3 (formerly 2B), regulatory subunit B, beta isoform".
- ↑ "PathCards :: MAPK signaling pathway Pathway and related pathways". pathcards.genecards.org. Retrieved 2015-09-08. horizontal tab character in
|title=at position 14 (help) - ↑ "PathCards :: GPCR Pathway Pathway and related pathways". pathcards.genecards.org. Retrieved 2015-09-08. horizontal tab character in
|title=at position 14 (help) - ↑ Database, GeneCards Human Gene. "PPP3R2 Gene - GeneCards | CANB2 Protein | CANB2 Antibody". www.genecards.org. Retrieved 2015-09-08.
Further reading
- Mukai H, Chang CD, Tanaka H, et al. (1991). "cDNA cloning of a novel testis-specific calcineurin B-like protein.". Biochem. Biophys. Res. Commun. 179 (3): 1325–30. doi:10.1016/0006-291X(91)91718-R. PMID 1718268.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Koefoed-Nielsen PB, Karamperis N, Højskov C, et al. (2007). "The calcineurin activity profiles of cyclosporin and tacrolimus are different in stable renal transplant patients". Transpl. Int. 19 (10): 821–7. doi:10.1111/j.1432-2277.2006.00359.x. PMID 16961774.
- Saeki M, Irie Y, Ni L, et al. (2007). "Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation". J. Biol. Chem. 282 (16): 11786–94. doi:10.1074/jbc.M609347200. PMID 17324936.
- Jang H, Cho EJ, Youn HD (2007). "A new calcineurin inhibition domain in Cabin1". Biochem. Biophys. Res. Commun. 359 (1): 129–35. doi:10.1016/j.bbrc.2007.05.066. PMID 17531200.
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