PPP3R1

Protein phosphatase 3, regulatory subunit B, alpha

PDB rendering based on 1aui.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1AUI, 1M63, 1MF8, 2P6B, 3LL8, 4F0Z, 4OR9, 4ORA, 4ORC

Identifiers

Symbols

PPP3R1 ; CALNB1; CNB; CNB1

External IDs

OMIM: 601302 MGI: 107172 HomoloGene: 68099 ChEMBL: 2082 GeneCards: PPP3R1 Gene

EC number

3.1.3.16

Gene ontology
Molecular function	• calcium-dependent protein serine/threonine phosphatase activity • calcium ion binding • protein binding • calmodulin binding • protein domain specific binding
Cellular component	• nucleoplasm • cytosol • calcineurin complex • sarcolemma
Biological process	• stimulatory C-type lectin receptor signaling pathway • protein dephosphorylation • apoptotic process • programmed cell death • calcineurin-NFAT signaling cascade • Fc-epsilon receptor signaling pathway • innate immune response • positive regulation of transcription from RNA polymerase II promoter • positive regulation of NFAT protein import into nucleus • intrinsic apoptotic signaling pathway • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
68.18 – 68.26 Mb

Chr 11:
17.16 – 17.2 Mb

PubMed search

Calcineurin subunit B type 1 also known as protein phosphatase 2B regulatory subunit 1 is a protein that in humans is encoded by the PPP3R1 gene.^[1]^[2]^[3]

Clinical significance

The presence of a single nucleotide polymorphism rs1868402 in the PPP3R1 gene is strongly correlated with rapid progress of Alzheimer's disease.^[4]

References

↑ Wang MG, Yi H, Guerini D, Klee CB, McBride OW (Jan 1997). "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively". Cytogenet Cell Genet 72 (2-3): 236–41. doi:10.1159/000134198. PMID 8978785.
↑ Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase". DNA 8 (9): 675–82. doi:10.1089/dna.1.1989.8.675. PMID 2558868.
↑ "Entrez Gene: PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform".
↑ Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, et al. (2010). Myers AJ, ed. "SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer's Disease". PLoS Genet 6 (9): e1001101. doi:10.1371/journal.pgen.1001101. PMC 2940763. PMID 20862329.

Kawamura A, Su MS (1995). "Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain.". J. Biol. Chem. 270 (26): 15463–6. doi:10.1074/jbc.270.26.15463. PMID 7541044.
Kissinger CR, Parge HE, Knighton DR, et al. (1996). "Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.". Nature 378 (6557): 641–4. doi:10.1038/378641a0. PMID 8524402.
Feng B, Stemmer PM (1999). "Interactions of calcineurin A, calcineurin B, and Ca2+.". Biochemistry 38 (38): 12481–9. doi:10.1021/bi990492w. PMID 10493818.
Stratakis CA, Taymans SE (1999). "Structure of the gene coding for calcineurin B (PPP3R1) and mapping to D2S358-D2S1778 (chromosomal region 2p15).". DNA Seq. 9 (4): 227–30. doi:10.3109/10425179809105209. PMID 10520753.
Nishio H, Matsui K, Tsuji H, et al. (2000). "Immunolocalization of calcineurin and FKBP12, the FK506-binding protein, in Hassall's corpuscles of human thymus and epidermis.". Histochem. Cell Biol. 114 (1): 9–14. doi:10.1007/s004180000168. PMID 10959817.
Sokal I, Li N, Verlinde CL, et al. (2001). "Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1).". Biochim. Biophys. Acta 1498 (2-3): 233–51. doi:10.1016/S0167-4889(00)00099-9. PMID 11108966.
Graef IA, Chen F, Chen L, et al. (2001). "Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.". Cell 105 (7): 863–75. doi:10.1016/S0092-8674(01)00396-8. PMID 11439183.
Al-Daraji WI, Grant KR, Ryan K, et al. (2002). "Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A.". J. Invest. Dermatol. 118 (5): 779–88. doi:10.1046/j.1523-1747.2002.01709.x. PMID 11982754.
Huai Q, Kim HY, Liu Y, et al. (2002). "Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes.". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12037–42. doi:10.1073/pnas.192206699. PMC 129394. PMID 12218175.
Jin L, Harrison SC (2002). "Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin.". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13522–6. doi:10.1073/pnas.212504399. PMC 129706. PMID 12357034.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.". Virology 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bittinger MA, McWhinnie E, Meltzer J, et al. (2005). "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins.". Curr. Biol. 14 (23): 2156–61. doi:10.1016/j.cub.2004.11.002. PMID 15589160.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Winslow MM, Gallo EM, Neilson JR, Crabtree GR (2006). "The calcineurin phosphatase complex modulates immunogenic B cell responses.". Immunity 24 (2): 141–52. doi:10.1016/j.immuni.2005.12.013. PMID 16473827.
Liu Q, Wilkins BJ, Lee YJ, et al. (2006). "Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth.". Mol. Cell. Biol. 26 (10): 3785–97. doi:10.1128/MCB.26.10.3785-3797.2006. PMC 1489013. PMID 16648474.

PDB gallery

1aui: HUMAN CALCINEURIN HETERODIMER

1m63: Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

1mf8: Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin

1tco: TERNARY COMPLEX OF A CALCINEURIN A FRAGMENT, CALCINEURIN B, FKBP12 AND THE IMMUNOSUPPRESSANT DRUG FK506 (TACROLIMUS)

2p6b: Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide

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PPP3R1

Clinical significance

References

Further reading