PPP3CC

Protein phosphatase 3, catalytic subunit, gamma isozyme
Identifiers
Symbols PPP3CC ; CALNA3; CNA3; PP2Bgamma
External IDs OMIM: 114107 MGI: 107162 HomoloGene: 68475 ChEMBL: 2694 GeneCards: PPP3CC Gene
EC number 3.1.3.16
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5533 19057
Ensembl ENSG00000120910 ENSMUSG00000022092
UniProt P48454 P48455
RefSeq (mRNA) NM_001243974 NM_001304991
RefSeq (protein) NP_001230903 NP_001291920
Location (UCSC) Chr 8:
22.44 – 22.54 Mb
Chr 14:
70.22 – 70.29 Mb
PubMed search

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PPP3CC gene.[1][2]

Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha (CALNA1; MIM 114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).[supplied by OMIM][2]

References

  1. Muramatsu T, Kincaid RL (Nov 1992). "Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A)". Biochem Biophys Res Commun 188 (1): 265–71. doi:10.1016/0006-291X(92)92379-C. PMID 1339277.
  2. 1 2 "Entrez Gene: PPP3CC protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform".

Further reading

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