PPP2R5B

Protein phosphatase 2, regulatory subunit B', beta

Identifiers

PPP2R5B ; B56B; PR61B

External IDs

OMIM: 601644 MGI: 2388480 HomoloGene: 38157 GeneCards: PPP2R5B Gene

Gene ontology
Molecular function	• protein binding • protein phosphatase type 2A regulator activity
Cellular component	• protein phosphatase type 2A complex • cytoplasm • cytosol
Biological process	• regulation of receptor activity • positive regulation of neuron projection development • endoplasmic reticulum unfolded protein response • positive regulation of protein complex assembly • regulation of protein autophosphorylation • regulation of protein phosphatase type 2A activity • IRE1-mediated unfolded protein response • cellular protein metabolic process • positive regulation of transcription from RNA polymerase II promoter • regulation of peptidyl-tyrosine phosphorylation • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of neurotrophin TRK receptor signaling pathway • negative regulation of G0 to G1 transition • positive regulation of cell cycle arrest • cellular response to growth factor stimulus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
64.92 – 64.93 Mb

Chr 19:
6.23 – 6.24 Mb

PubMed search

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform is an enzyme that in humans is encoded by the PPP2R5B gene.^[1]^[2]

Function

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily.^[2]

Interactions

PPP2R5B has been shown to interact with PPP2R1B^[3] and PPP2CA.^[3]^[4]

References

↑ McCright B, Virshup DM (Nov 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". The Journal of Biological Chemistry 270 (44): 26123–8. doi:10.1074/jbc.270.44.26123. PMID 7592815.
1 2 "Entrez Gene: PPP2R5B protein phosphatase 2, regulatory subunit B', beta isoform".
1 2 McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. PMID 8703017.
↑ Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353.
Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research 121 (4): 270–86. PMID 15817944.
Cross SH, Charlton JA, Nan X, Bird AP (Mar 1994). "Purification of CpG islands using a methylated DNA binding column". Nature Genetics 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384.
Zolnierowicz S, Van Hoof C, Andjelković N, Cron P, Stevens I, Merlevede W, Goris J, Hemmings BA (Jul 1996). "The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits". The Biochemical Journal. 317 ( Pt 1) (1): 187–94. PMC 1217462. PMID 8694763.
McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. PMID 8703017.
McCright B, Brothman AR, Virshup DM (Aug 1996). "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12". Genomics 36 (1): 168–70. doi:10.1006/geno.1996.0438. PMID 8812429.
Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (Jan 1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters 401 (2-3): 197–201. doi:10.1016/S0014-5793(96)01470-6. PMID 9013886.
Forbes SA, Pannett AA, Bassett JH, Harding B, Wooding C, Thakker RV, Butler R, Ogilvie D, Anand R, Gaudray P, Weber G, Larsson C, Zhang CX, Calender A, Höppener JW, Lips CJ, Kas K (Sep 1997). "Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1)". Human Genetics 100 (3-4): 481–5. doi:10.1007/s004390050538. PMID 9272177.
Ruediger R, Brewis N, Ohst K, Walter G (Nov 1997). "Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production". Virology 238 (2): 432–43. doi:10.1006/viro.1997.8873. PMID 9400615.
Ikeda S, Kishida M, Matsuura Y, Usui H, Kikuchi A (Jan 2000). "GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin". Oncogene 19 (4): 537–45. doi:10.1038/sj.onc.1203359. PMID 10698523.
Hrimech M, Yao XJ, Branton PE, Cohen EA (Aug 2000). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". The EMBO Journal 19 (15): 3956–67. doi:10.1093/emboj/19.15.3956. PMC 306605. PMID 10921877. (Retracted)
Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (Sep 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.
Hrimech M, Yao XJ, Branton PE, Cohen EA (Jul 2002). "Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A". The EMBO Journal 21 (14): 3918. doi:10.1093/emboj/cdf420. PMC 126131. PMID 12110603.
Galey D, Becker K, Haughey N, Kalehua A, Taub D, Woodward J, Mattson MP, Nath A (Jun 2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". Journal of Neurovirology 9 (3): 358–71. doi:10.1080/13550280390201119. PMID 12775419.
Dozier C, Bonyadi M, Baricault L, Tonasso L, Darbon JM (Sep 2004). "Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit". Biology of the Cell / Under the Auspices of the European Cell Biology Organization 96 (7): 509–17. doi:10.1016/j.biolcel.2004.04.010. PMID 15380617.

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PPP2R5B

Function

Interactions

References

Further reading