PPIH

Peptidylprolyl isomerase H (cyclophilin H)

PDB rendering based on 1mzw.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PPIH ; CYP-20; CYPH; SnuCyp-20; USA-CYP
External IDs OMIM: 606095 MGI: 106499 HomoloGene: 38172 GeneCards: PPIH Gene
EC number 5.2.1.8
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 10465 66101
Ensembl ENSG00000171960 ENSMUSG00000060288
UniProt O43447 Q9D868
RefSeq (mRNA) NM_006347 NM_001110129
RefSeq (protein) NP_006338 NP_001103599
Location (UCSC) Chr 1:
42.66 – 42.68 Mb
Chr 4:
119.3 – 119.32 Mb
PubMed search

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.[1][2][3]

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.[3]

References

Further reading

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