POLR2I

Polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa

Identifiers

POLR2I ; RPB9; hRPB14.5

External IDs

OMIM: 180662 MGI: 1917170 HomoloGene: 4541 GeneCards: POLR2I Gene

2.7.7.6

Gene ontology
Molecular function	• DNA binding • DNA-directed RNA polymerase activity • zinc ion binding
Cellular component	• nucleus • nucleoplasm • DNA-directed RNA polymerase II, core complex • nucleolus
Biological process	• mRNA splicing, via spliceosome • maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter • DNA repair • transcription-coupled nucleotide-excision repair • nucleotide-excision repair • transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • transcription elongation from RNA polymerase II promoter • 7-methylguanosine mRNA capping • RNA splicing • gene expression • viral process • piRNA metabolic process • somatic stem cell maintenance • positive regulation of viral transcription
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 19:
36.11 – 36.12 Mb

Chr 7:
30.23 – 30.23 Mb

PubMed search

DNA-directed RNA polymerase II subunit RPB9 is an enzyme that in humans is encoded by the POLR2I gene.^[1]

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity.^[2]

References

↑ Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (Aug 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics 20 (3): 496–9. doi:10.1006/geno.1994.1208. PMID 8034326.
↑ "Entrez Gene: POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa".

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POLR2I

References

Further reading