PLEKHA1

Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1

PDB rendering based on 1eaz.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1EAZ

Identifiers

Symbols

PLEKHA1 ; TAPP1

External IDs

OMIM: 607772 MGI: 2442213 HomoloGene: 11001 GeneCards: PLEKHA1 Gene

Gene ontology
Molecular function	• protein binding • PDZ domain binding • phosphatidylinositol-3,4-bisphosphate binding
Cellular component	• nucleoplasm • cytoplasm • plasma membrane • ruffle membrane • extracellular exosome
Biological process	• luteinization • spermatogenesis • androgen metabolic process • estrogen metabolic process • post-embryonic development • phosphatidylinositol 3-kinase signaling • ruffle organization • Leydig cell differentiation • multicellular organism growth • establishment of protein localization • platelet-derived growth factor receptor signaling pathway • skeletal system morphogenesis • B cell receptor signaling pathway • negative regulation of protein kinase B signaling • palate development • face morphogenesis • cellular response to hydrogen peroxide
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
122.37 – 122.44 Mb

Chr 7:
130.87 – 130.91 Mb

PubMed search

Pleckstrin homology domain-containing family A member 1 is a protein that in humans is encoded by the PLEKHA1 gene.^[1]^[2]^[3]

Interactions

PLEKHA1 has been shown to interact with MPDZ.^[4]

References

↑ Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (Jan 2001). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem J 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
↑ Hogan A, Yakubchyk Y, Chabot J, Obagi C, Daher E, Maekawa K, Gee SH (Dec 2004). "The phosphoinositol 3,4-bisphosphate-binding protein TAPP1 interacts with syntrophins and regulates actin cytoskeletal organization". J Biol Chem 279 (51): 53717–24. doi:10.1074/jbc.M410654200. PMID 15485858.
↑ "Entrez Gene: PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1".
↑ Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR (Feb 2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. 361 (Pt 3): 525–36. doi:10.1042/0264-6021:3610525. PMC 1222335. PMID 11802782.

Thomas CC, Dowler S, Deak M, Alessi DR, van Aalten DM (2001). "Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity". Biochem. J. 358 (Pt 2): 287–94. doi:10.1042/0264-6021:3580287. PMC 1222060. PMID 11513726.
Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR (2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. 361 (Pt 3): 525–36. doi:10.1042/0264-6021:3610525. PMC 1222335. PMID 11802782.
Marshall AJ, Krahn AK, Ma K, Duronio V, Hou S (2002). "TAPP1 and TAPP2 Are Targets of Phosphatidylinositol 3-Kinase Signaling in B Cells: Sustained Plasma Membrane Recruitment Triggered by the B-Cell Antigen Receptor". Mol. Cell. Biol. 22 (15): 5479–91. doi:10.1128/MCB.22.15.5479-5491.2002. PMC 133950. PMID 12101241.
Kimber WA, Deak M, Prescott AR, Alessi DR (2003). "Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1". Biochem. J. 376 (Pt 2): 525–35. doi:10.1042/BJ20031154. PMC 1223793. PMID 14516276.
Jakobsdottir J, Conley YP, Weeks DE, Mah TS, Ferrell RE, Gorin MB (2006). "Susceptibility Genes for Age-Related Maculopathy on Chromosome 10q26". Am. J. Hum. Genet. 77 (3): 389–407. doi:10.1086/444437. PMC 1226205. PMID 16080115.

PDB gallery

1eaz: CRYSTAL STRUCTURE OF THE PHOSPHOINOSITOL (3,4)-BISPHOSPHATE BINDING PH DOMAIN OF TAPP1 FROM HUMAN.

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PLEKHA1

Interactions

References

Further reading