PLD5

Phospholipase D family, member 5
Identifiers
Symbols PLD5 ; PLDC
External IDs HomoloGene: 16081 GeneCards: PLD5 Gene
Orthologs
Species Human Mouse
Entrez 200150 319455
Ensembl ENSG00000180287 ENSMUSG00000055214
UniProt Q8N7P1 Q3UNN8
RefSeq (mRNA) NM_001195811 NM_001195816
RefSeq (protein) NP_001182740 NP_001182745
Location (UCSC) Chr 1:
242.08 – 242.52 Mb		 Chr 1:
175.96 – 176.28 Mb
PubMed search

Phospholipase D family, member 5 is a protein that in humans is encoded by the PLD5 gene.[1]

Model organisms

Model organisms have been used in the study of PLD5 function. A conditional knockout mouse line, called Pld5tm1a(KOMP)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.[4]

References

  1. ↑ "Entrez Gene: PLD5 phospholipase D family, member 5". Retrieved 2011-12-04.
  2. ↑ "Salmonella infection data for Pld5". Wellcome Trust Sanger Institute.
  3. ↑ "Citrobacter infection data for Pld5". Wellcome Trust Sanger Institute.
  4. 1 2 3 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x.
  5. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. ↑ "International Knockout Mouse Consortium".
  7. ↑ "Mouse Genome Informatics".
  8. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  9. ↑ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  10. ↑ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  11. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading


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