PLAGL1

Pleiomorphic adenoma gene-like 1

Identifiers

PLAGL1 ; LOT1; ZAC; ZAC1

External IDs

OMIM: 603044 HomoloGene: 31401 GeneCards: PLAGL1 Gene

Gene ontology
Molecular function	• RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • DNA binding • metal ion binding
Cellular component	• nucleus • nucleoplasm • Golgi apparatus • intracellular membrane-bounded organelle
Biological process	• transcription from RNA polymerase II promoter • apoptotic process • cell cycle arrest • cell differentiation • skeletal muscle cell differentiation • positive regulation of transcription from RNA polymerase II promoter
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
143.94 – 144.06 Mb

Chr 10:
13.06 – 13.13 Mb

PubMed search

Zinc finger protein PLAGL1 is a protein that in humans is encoded by the PLAGL1 gene.^[1]^[2]^[3]

Function

This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activity. This gene has been shown to exhibit antiproliferative activities and is a tumor suppressor gene candidate. Many transcript variants encoding two different isoforms have been found for this gene.^[3]

Interactions

PLAGL1 has been shown to interact with P53.^[4]

References

↑ Kas K, Voz ML, Hensen K, Meyen E, Van de Ven WJ (Oct 1998). "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins". J. Biol. Chem. 273 (36): 23026–32. doi:10.1074/jbc.273.36.23026. PMID 9722527.
↑ Varrault A, Ciani E, Apiou F, Bilanges B, Hoffmann A, Pantaloni C, Bockaert J, Spengler D, Journot L (Aug 1998). "hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8835–40. doi:10.1073/pnas.95.15.8835. PMC 21163. PMID 9671765.
1 2 "Entrez Gene: PLAGL1 pleiomorphic adenoma gene-like 1".
↑ Huang SM, Schönthal AH, Stallcup MR (Apr 2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197.

Vernon M (2005). "Fifty years of research on the intelligence of deaf and hard-of-hearing children: a review of literature and discussion of implications". J Deaf Stud Deaf Educ 10 (3): 225–31. doi:10.1093/deafed/eni024. PMID 15888725.
Abdollahi A, Roberts D, Godwin AK, Schultz DC, Sonoda G, Testa JR, Hamilton TC (1997). "Identification of a zinc-finger gene at 6q25: a chromosomal region implicated in development of many solid tumors". Oncogene 14 (16): 1973–9. doi:10.1038/sj.onc.1201034. PMID 9150364.
Abdollahi A, Godwin AK, Miller PD, Getts LA, Schultz DC, Taguchi T, Testa JR, Hamilton TC (1997). "Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells". Cancer Res. 57 (10): 2029–34. PMID 9158001.
Spengler D, Villalba M, Hoffmann A, Pantaloni C, Houssami S, Bockaert J, Journot L (1997). "Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain". EMBO J. 16 (10): 2814–25. doi:10.1093/emboj/16.10.2814. PMC 1169890. PMID 9184226.
Abdollahi A, Bao R, Hamilton TC (1999). "LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein". Oncogene 18 (47): 6477–87. doi:10.1038/sj.onc.1203067. PMID 10597250.
Kamiya M, Judson H, Okazaki Y, Kusakabe M, Muramatsu M, Takada S, Takagi N, Arima T, Wake N, Kamimura K, Satomura K, Hermann R, Bonthron DT, Hayashizaki Y (2000). "The cell cycle control gene ZAC/PLAGL1 is imprinted--a strong candidate gene for transient neonatal diabetes". Hum. Mol. Genet. 9 (3): 453–60. doi:10.1093/hmg/9.3.453. PMID 10655556.
Bilanges B, Varrault A, Mazumdar A, Pantaloni C, Hoffmann A, Bockaert J, Spengler D, Journot L (2001). "Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities". Oncogene 20 (10): 1246–53. doi:10.1038/sj.onc.1204237. PMID 11313869.
Huang SM, Schönthal AH, Stallcup MR (2001). "Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1". Oncogene 20 (17): 2134–43. doi:10.1038/sj.onc.1204298. PMID 11360197.
Mackay DJ, Coupe AM, Shield JP, Storr JN, Temple IK, Robinson DO (2002). "Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus". Hum. Genet. 110 (2): 139–44. doi:10.1007/s00439-001-0671-5. PMID 11935319.
Abdollahi A, Pisarcik D, Roberts D, Weinstein J, Cairns P, Hamilton TC (2003). "LOT1 (PLAGL1/ZAC1), the candidate tumor suppressor gene at chromosome 6q24-25, is epigenetically regulated in cancer". J. Biol. Chem. 278 (8): 6041–9. doi:10.1074/jbc.M210361200. PMID 12473647.
Hoffmann A, Ciani E, Boeckardt J, Holsboer F, Journot L, Spengler D (2003). "Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding". Mol. Cell. Biol. 23 (3): 988–1003. doi:10.1128/MCB.23.3.988-1003.2003. PMC 140694. PMID 12529403.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Ma D, Shield JP, Dean W, Leclerc I, Knauf C, Burcelin R, Rutter GA, Kelsey G (2004). "Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM". J. Clin. Invest. 114 (3): 339–48. doi:10.1172/JCI200419876. PMC 484972. PMID 15286800.
Cvetkovic D, Pisarcik D, Lee C, Hamilton TC, Abdollahi A (2004). "Altered expression and loss of heterozygosity of the LOT1 gene in ovarian cancer". Gynecol. Oncol. 95 (3): 449–55. doi:10.1016/j.ygyno.2004.08.051. PMID 15581945.
Mitchell J, Punthakee Z, Lo B, Bernard C, Chong K, Newman C, Cartier L, Desilets V, Cutz E, Hansen IL, Riley P, Polychronakos C (2004). "Neonatal diabetes, with hypoplastic pancreas, intestinal atresia and gall bladder hypoplasia: search for the aetiology of a new autosomal recessive syndrome". Diabetologia 47 (12): 2160–7. doi:10.1007/s00125-004-1576-3. PMID 15592663.

This article is issued from Wikipedia - version of the Wednesday, September 02, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

PLAGL1

Function

Interactions

References

Further reading