PIK3C3

Phosphatidylinositol 3-kinase, catalytic subunit type 3

Rendering based on PDB 3IHY.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3IHY, 3LS8, 4OYS, 4PH4, 4UWF, 4UWG, 4UWH, 4UWK, 4UWL

Identifiers

Symbols

PIK3C3 ; VPS34; Vps34; hVps34

External IDs

OMIM: 602609 MGI: 2445019 HomoloGene: 1986 ChEMBL: 1075165 GeneCards: PIK3C3 Gene

EC number

2.7.1.137

Gene ontology
Molecular function	• protein kinase activity • protein binding • ATP binding • 1-phosphatidylinositol-3-kinase activity
Cellular component	• pre-autophagosomal structure • cytoplasm • late endosome • autophagosome • peroxisome • cytosol • axoneme • membrane • midbody • phosphatidylinositol 3-kinase complex, class III, type I • phosphatidylinositol 3-kinase complex, class III, type II • phosphatidylinositol 3-kinase complex, class III • phagocytic vesicle
Biological process	• autophagosome assembly • cytokinesis • toll-like receptor signaling pathway • protein phosphorylation • phospholipid metabolic process • phosphatidylinositol biosynthetic process • endocytosis • endosome organization • insulin receptor signaling pathway • macroautophagy • protein processing • pexophagy • regulation of cytokinesis • toll-like receptor 9 signaling pathway • phosphatidylinositol-3-phosphate biosynthetic process • cellular response to glucose starvation • response to leucine • small molecule metabolic process • early endosome to late endosome transport • innate immune response • phosphatidylinositol phosphorylation • phosphatidylinositol-mediated signaling • regulation of protein secretion
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 18:
41.96 – 42.09 Mb

Chr 18:
30.27 – 30.35 Mb

PubMed search

Phosphatidylinositol 3-kinase catalytic subunit type 3 is an enzyme that in humans is encoded by the PIK3C3 gene.^[1]^[2]

References

↑ Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ, Domin J, Panaretou C, Waterfield MD (Sep 1995). "A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system". EMBO J 14 (14): 3339–48. PMC 394401. PMID 7628435.
↑ "Entrez Gene: PIK3C3 phosphoinositide-3-kinase, class 3".

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Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.". Biochem. Biophys. Res. Commun. 242 (2): 332–7. doi:10.1006/bbrc.1997.7877. PMID 9446795.
Milani D, Mazzoni M, Zauli G, et al. (1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.". AIDS 12 (11): 1275–84. doi:10.1097/00002030-199811000-00008. PMID 9708406.
Jauliac S, Mazerolles F, Jabado N, et al. (1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity.". Eur. J. Immunol. 28 (10): 3183–91. doi:10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A. PMID 9808187.
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Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.
Deregibus MC, Cantaluppi V, Doublier S, et al. (2002). "HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells.". J. Biol. Chem. 277 (28): 25195–202. doi:10.1074/jbc.M200921200. PMID 11994280.
Cook JA, August A, Henderson AJ (2002). "Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.". J. Immunol. 169 (1): 254–60. doi:10.4049/jimmunol.169.1.254. PMID 12077252.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
François F, Klotman ME (2003). "Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages.". J. Virol. 77 (4): 2539–49. doi:10.1128/JVI.77.4.2539-2549.2003. PMC 141101. PMID 12551992.
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PIK3C3

References

Further reading